Cardiac allograft survival in mice treated with IL-2-PE40.
1989; National Academy of Sciences; Volume: 86; Issue: 3 Linguagem: Inglês
10.1073/pnas.86.3.1008
ISSN1091-6490
AutoresHaya Lorberboum‐Galski, Leslie V. Barrett, Robert L. Kirkman, M Ogata, Mark C. Willingham, David J. FitzGerald, Ira Pastan,
Tópico(s)Toxin Mechanisms and Immunotoxins
ResumoIL-2-PE40 is a chimeric protein composed of human interleukin 2 (IL-2) genetically fused to the amino terminus of a modified form of Pseudomonas exotoxin lacking its cell recognition domain. IL-2-PE40, which is extremely cytotoxic to IL-2 receptor-positive cells, was examined for its ability to prevent graft rejection in mice in which activation of T cells is prominent. We demonstrate that intraperitoneally administered IL-2-PE40 specifically and significantly prolongs the survival of vascularized heart allografts in mice. The chimeric toxin, IL-2-PE40, offers an alternative approach to the treatment of autoimmune diseases and transplant rejection in humans.
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