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Chloromycetin (Chloramphenicol) in the Treatment of Infections

1950; Massachusetts Medical Society; Volume: 242; Issue: 4 Linguagem: Inglês

10.1056/nejm195001262420402

1533-4406

William L. Hewitt, Bryan J. Williams,

Antibiotic Resistance in Bacteria

CHLOROMYCETIN (chloramphenicol) is a white crystalline antibiotic agent isolated originally from Streptomyces venezuelae.1 The chemical formula has been determined,2 and the manufacture of the compound by chemical synthesis has been accomplished on a commercially practicable basis. It is an extremely bitter material, relatively stable in water over a wide range of temperature and pH and sparingly soluble in water to the extent of 2.5 mg. per cubic centimeter. Previous studies have shown Chloromycetin to be active against a wide spectrum of bacteria in vitro, including many gram-positive cocci, the gonococcus and most of the gram-negative bacilli except certain strains . . .