Is Clonidine Useful in the Treatment of Alcohol Withdrawal?
1989; Wiley; Volume: 13; Issue: 1 Linguagem: Inglês
10.1111/j.1530-0277.1989.tb00290.x
ISSN1530-0277
AutoresBrian Robinson, Geoffrey Robinson, Maling Tj, Ralph H. Johnson,
Tópico(s)Eicosanoids and Hypertension Pharmacology
ResumoThe comparative efficacy of clonidine and chlormethiazole has been examined in the management of acute alcohol withdrawal. A double blind randomized study was conducted in consecutive patients admitted to a hospital detoxification unit. Patients were assessed regularly by a standard alcohol withdrawal rating‐scale. Thirty‐two patients received either clonidine or chlormethiazole in reducing dosages over 96 hr. All the patients receiving chlormethiazole had uneventful withdrawals. However, eight patients treated with clonidine were withdrawn from the trial due to hallucinations (two), seizures (two), symptomatic orthostatic hypotension (three) or drowsiness (one), indicating that clonidine is less effective than chlormethiazole in the prevention of the major manifestations of alcohol withdrawal.
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