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The effect of 1-(morpholinomethyl)-4-phtalimido-piperidindione-2,6 and drostanolone propionate on the plasma prolactin concentration of oestrone-treated orchidectomized R-Amsterdam rats

1971; Pergamon Press; Volume: 7; Issue: 6 Linguagem: Inglês

10.1016/0014-2964(71)90066-1

1879-2995

A. A. van der Gugten,

Estrogen and related hormone effects

The influence of drostanolone propionate, an anticancer agent, was tested on the binding of 17 β-oestradiol and dihydrotestosterone to specific receptor proteins in tissue of normal and neoplastic target organs. Steroid binding capacity was measured by agar gel electrophoresis of tissue extracts.Drostanolone was found to compete with androgen binding sites but not with oestrogen receptors. Therefore it is unlikely that the growth inhibitory effect of drostanolone propionate in human breast cancer is mediated through interaction with oestradiol binding proteins as suggested earlier by other authors.