Alzheimer's Disease: X-Ray Spectrometric Evidence of Aluminum Accumulation in Neurofibrillary Tangle-Bearing Neurons
1980; American Association for the Advancement of Science; Volume: 208; Issue: 4441 Linguagem: Inglês
10.1126/science.7367858
ISSN1095-9203
AutoresDaniel P. Perl, Arnold R. Brody,
Tópico(s)Pharmacological Effects of Medicinal Plants
ResumoThe elemental content of neurons of the hippocampus was studied by a combination of scanning electron microscopy and x-ray spectrometry in autopsy-derived brain tissue from three cases of senile dementia (Alzheimer type) and three nondemented elderly controls. Foci of aluminum were detected within the nuclear region of a high percentage of neurons containing neurofibrillary tangles from the cases of senile dementia as well as the elderly controls. The adjacent normal-appearing neurons from both groups of patients were virtually free of detectable aluminum. These findings suggest that the association of aluminum to Alzheimer's disease extends to the neuronal level.
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