HIV prevention research: the ecstasy and the agony
2008; Elsevier BV; Volume: 372; Issue: 9654 Linguagem: Inglês
10.1016/s0140-6736(08)61824-3
ISSN1474-547X
AutoresWillard Cates, Paul J. Feldblum,
Tópico(s)Cervical Cancer and HPV Research
ResumoOver the past 2 years, The Lancet has proactively championed HIV prevention science. It published a state-of-the-art series on HIV prevention, timed for the 2008 Mexico City International AIDS Conference, 1 Horton R Das P Putting prevention at the forefront of HIV/AIDS. Lancet. 2008; 372: 421-422 Summary Full Text Full Text PDF PubMed Scopus (47) Google Scholar and six other primary publications from key HIV-prevention trials. The two trials that showed male circumcision protected against HIV acquisition were uplifting. 2 Bailey RC Moses S Parker CB et al. Male circumcision for HIV prevention in young men in Kisumu, Kenya: a randomised controlled trial. Lancet. 2007; 369: 643-656 Summary Full Text Full Text PDF PubMed Scopus (1785) Google Scholar , 3 Gray RH Kigozi G Serwadda D et al. Male circumcision for HIV prevention in men in Rakai, Uganda: a randomised trial. Lancet. 2007; 369: 657-666 Summary Full Text Full Text PDF PubMed Scopus (1756) Google Scholar Disappointingly, four other trials failed to show that the diaphragm, 4 Padian NS van der Straten A Ramjee G et al. the MIRA TeamDiaphragm and lubricant gel for prevention of HIV acquisition in southern African women: a randomised controlled trial. Lancet. 2007; 370: 251-261 Summary Full Text Full Text PDF PubMed Scopus (286) Google Scholar prophylaxis for herpes simplex virus type 2, 5 Celum C Wald A Hughes J et al. the HPTN 039 Protocol TeamEffect of aciclovir on HIV-1 acquisition in herpes simplex virus 2 seropositive women and men who have sex with men: a randomised, double-blind, placebo-controlled trial. Lancet. 2008; 371: 2109-2119 Summary Full Text Full Text PDF PubMed Scopus (376) Google Scholar an HIV vaccine, 6 Buchbinder SP Mehrotra DV Duerr A et al. for the the Step Study Protocol TeamEfficacy assessment of a cell-mediated immunity HIV-1 vaccine (the Step Study): a double-blind, randomised, placebo-controlled, test-of-concept trial. Lancet. 2008; 374: 1881-1893 Summary Full Text Full Text PDF Scopus (1426) Google Scholar and now Carraguard as a topical microbicide 7 Skoler-Karpoff S Ramjee G Ahmed K et al. Efficacy of Carraguard for prevention of HIV infection in women in South Africa: a randomised, double-blind, placebo-controlled trial. Lancet. 2008; 372: 1977-1987 Summary Full Text Full Text PDF PubMed Scopus (434) Google Scholar are effective in preventing HIV. Such is the ecstasy and the agony of HIV-prevention research. Efficacy of Carraguard for prevention of HIV infection in women in South Africa: a randomised, double-blind, placebo-controlled trialThis study did not show Carraguard's efficacy in prevention of vaginal transmission of HIV. No safety concerns were recorded. Full-Text PDF
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