Myofibroblasts in human granulation tissue
1974; Elsevier BV; Volume: 5; Issue: 1 Linguagem: Inglês
10.1016/s0046-8177(74)80100-0
ISSN1532-8392
AutoresGraeme B. Ryan, W. J. Cliff, Giulio Gabbiani, Claude Irlé, Denys Montandon, P. R. Statkov, Guido Majno,
Tópico(s)3D Printing in Biomedical Research
ResumoFibroblasts of human granulation tissues develop structural and functional features typical of smooth muscle cells:o1.They contain massive bundles of intracytoplasmic microfilaments.2.Their cytoplasm shows immunofluorescent labeling with human antismooth muscle serum.3.The nuclei have multiple indentations and deep folds, indicative of contraction.4.There are cell-to-cell and cell-to-stroma connections whereby cellular contraction could be transmitted to the tissue as a whole.5.Strips of granulation tissue, when tested pharmacologically in vitro, contract or relax similarly to smooth muscle. They contain massive bundles of intracytoplasmic microfilaments. Their cytoplasm shows immunofluorescent labeling with human antismooth muscle serum. The nuclei have multiple indentations and deep folds, indicative of contraction. There are cell-to-cell and cell-to-stroma connections whereby cellular contraction could be transmitted to the tissue as a whole. Strips of granulation tissue, when tested pharmacologically in vitro, contract or relax similarly to smooth muscle. It is proposed that these modified fibroblasts, or “myofibroblasts,” are responsible for the contraction of granulation tissue, a process useful in closing wounds though potentially harmful in other situations.
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