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A cross-species socio-emotional behaviour development revealed by a multivariate analysis

2013; Nature Portfolio; Volume: 3; Issue: 1 Linguagem: Inglês

10.1038/srep02630

2045-2322

Mamiko Koshiba, Aya Senoo, Koki Mimura, Yuka Shirakawa, Genta Karino, Saya Obara, Shinpei Ozawa, Hitomi Sekihara, Yuta Fukushima, Toyotoshi Ueda, Hirohisa Kishino, Toshihisa Tanaka, Hidetoshi Ishibashi, Hideo Yamanouchi, Kunio Yui, Shun Nakamura,

Primate Behavior and Ecology

Abstract Recent progress in affective neuroscience and social neurobiology has been propelled by neuro-imaging technology and epigenetic approach in neurobiology of animal behaviour. However, quantitative measurements of socio-emotional development remains lacking, though sensory-motor development has been extensively studied in terms of digitised imaging analysis. Here, we developed a method for socio-emotional behaviour measurement that is based on the video recordings under well-defined social context using animal models with variously social sensory interaction during development. The behaviour features digitized from the video recordings were visualised in a multivariate statistic space using principal component analysis. The clustering of the behaviour parameters suggested the existence of species- and stage-specific as well as cross-species behaviour modules. These modules were used to characterise the behaviour of children with or without autism spectrum disorders (ASDs). We found that socio-emotional behaviour is highly dependent on social context and the cross-species behaviour modules may predict neurobiological basis of ASDs.