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(+)-Nortrachelogenin, A New Pharmacologically Active Lignan From Wikstroemia indica

1979; American Chemical Society; Volume: 42; Issue: 2 Linguagem: Inglês

10.1021/np50002a004

1520-6025

Atsushi Kato, Yosuke Hashimoto, M. Kidokor,

Bioactive Natural Diterpenoids Research

A new lignan, (+)-nortrachelogenin (I), and a known compound, daphnoretin were isolated from Wikstroemia indica C. A. Meyer (Thymelaeaceae). The structure of (+)-nortrachelogenin was established as 8(R), 8'(R)-4,4',8'-trihydroxy-3,3'-dimethoxylignan-olid(9, 9') on the basis of spectroscopic evidence and comparison with its enantiomer, (-)-nortrachelogenin. (+)-Nortrachelogenin (I) showed effects on the central nervous system producing depression in rabbits.