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CHANGES OF CIRCULATORY–METABOLIC INDICES AND SKULL BIOMECHANICS WITH BRAIN ACTIVITY DURING AGING

2011; Imperial College Press; Volume: 10; Issue: 02 Linguagem: Inglês

10.1142/s021963521100266x

1757-448X

Yu. E. Moskalenko, N. A. Ryabchikova, G. B. Weinstein, P. Halvorson, T Vardy,

Advanced MRI Techniques and Applications

Journal of Integrative NeuroscienceVol. 10, No. 02, pp. 131-160 (2011) No AccessCHANGES OF CIRCULATORY–METABOLIC INDICES AND SKULL BIOMECHANICS WITH BRAIN ACTIVITY DURING AGINGY. E. MOSKALENKO, N. A. RYABCHIKOVA, G. B. WEINSTEIN, P. HALVORSON, and T. C. VARDYY. E. MOSKALENKOSechenov Institute of Evolutionary Physiology and Biochemistry of the Russian Academy of Sciences, Thorez Prosp. 44, St. Petersburg 194223, Russian FederationCorresponding author. Search for more papers by this author , N. A. RYABCHIKOVADept. of Higher Nervous Activity, Biology Faculty, Lomonosov Moscow State University, Vorobyevi Gory Moscow 119899, Russian Federation Search for more papers by this author , G. B. WEINSTEINSechenov Institute of Evolutionary Physiology and Biochemistry of the Russian Academy of Sciences, Thorez Prosp. 44, St. Petersburg 194223, Russian Federation Search for more papers by this author , P. HALVORSONSechenov Institute of Evolutionary Physiology and Biochemistry of the Russian Academy of Sciences, Thorez Prosp. 44, St. Petersburg 194223, Russian Federation Search for more papers by this author , and T. C. VARDYSechenov Institute of Evolutionary Physiology and Biochemistry of the Russian Academy of Sciences, Thorez Prosp. 44, St. Petersburg 194223, Russian Federation Search for more papers by this author https://doi.org/10.1142/S021963521100266XCited by:5 Next AboutSectionsPDF/EPUB ToolsAdd to favoritesDownload CitationsTrack CitationsRecommend to Library ShareShare onFacebookTwitterLinked InRedditEmail AbstractThe cerebral blood flow values used in experimental and clinical investigations as the informative criteria for brain blood supply are often misleading. The correlation between the cerebral blood supply and brain function is not proven in all cases. An increase of brain activity is known to be accompanied by a rise of blood flow in activated regions, while a decreased activity results in a decreased blood flow. This demonstrates the close correlation between the brain blood supply and its activity. Such a correlation had not been noted in the age-dependent decrease of cerebral blood flow, suggesting the existence of special age-related mechanisms that develop with age to maintain brain metabolism.The biomechanical properties are of special significance as predicted in the early 20th century. Only recently were they validated by the simultaneous recording of Transcranial Dopplerogram and Rheoencephalogram with in-depth analysis focused on single cardiac cycles. Functioning of the intracranial blood and cerebrospinal fluid dynamics was integrated with a special physiological test "Prognosis-2" to measure brain cognitive function. 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Weinstein9 April 2013 | Journal of Evolutionary Biochemistry and Physiology, Vol. 49, No. 1 Recommended Vol. 10, No. 02 Metrics History Received 22 September 2010 Accepted 25 April 2011 KeywordsCerebral circulationCSF dynamicsskull biomechanicsbrain cognitive functionPDF download