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Neutrophil to lymphocyte ratio as a measure of systemic inflammation in psoriasis

2013; Taylor & Francis; Volume: 33; Issue: 3 Linguagem: Inglês

10.3109/15569527.2013.834498

1556-9535

Bilge Bülbül Şen, Emine Nur Rifaioğlu, Özlem Ekiz, Mehmet Uğur İnan, Tuğba Şen, Nihat Şen,

Spondyloarthritis Studies and Treatments

Objective: Psoriasis is a chronic systemic inflammatory disorder. The neutrophil to lymphocyte ratio (N/L ratio) has been used as a marker for systemic inflammatory status. In our study, we aimed to evaluate N/L ratio in patients with psoriasis.Methods: This cross-sectional study population consisted of 138 patients with psoriasis and 120 age- and sex-matched control subjects.Results: The patients had significantly higher neutrophil counts and lower lymphocyte counts than the controls. The N/L ratios and high sensitivity C reactive protein (hs-CRP) levels were also significantly higher in patients. The N/L ratios and hs-CRP levels were increasing with increasing in Psoriasis Area and Severity Index score. Furthermore, the N/L ratios and hs-CRP levels of patients were found to be positively correlated.Conclusions: Our data show that the N/L ratio to be a simple, inexpensive and easily assessable marker of systemic inflammation in patients with psoriasis.