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Scission of DNA with Bis(1,10‐phenanthroline)copper without Intramolecular Hydrogen Migration

1997; Wiley; Volume: 36; Issue: 24 Linguagem: Inglês

10.1002/anie.199727761

1521-3773

Ottilie Zelenko, James J. Gallagher, David S. Sigman,

Chemical Reaction Mechanisms

Angewandte Chemie International Edition in EnglishVolume 36, Issue 24 p. 2776-2778 Communication Scission of DNA with Bis(1,10-phenanthroline)copper without Intramolecular Hydrogen Migration† Ottilie Zelenko, Ottilie Zelenko Department of Biological Chemistry, School of Medicine, Department of Chemistry and Biochemistry and Molecular Biology Institute, Univerisity of California, Los Angeles, CA 90095-1570 (USA), Fax: Int. code +(310) 206-7286, e-mail: [email protected]Search for more papers by this authorJames Gallagher, James Gallagher Department of Biological Chemistry, School of Medicine, Department of Chemistry and Biochemistry and Molecular Biology Institute, Univerisity of California, Los Angeles, CA 90095-1570 (USA), Fax: Int. code +(310) 206-7286, e-mail: [email protected]Search for more papers by this authorProf. David S. Sigman, Corresponding Author Prof. David S. Sigman Department of Biological Chemistry, School of Medicine, Department of Chemistry and Biochemistry and Molecular Biology Institute, Univerisity of California, Los Angeles, CA 90095-1570 (USA), Fax: Int. code +(310) 206-7286, e-mail: [email protected]Department of Biological Chemistry, School of Medicine, Department of Chemistry and Biochemistry and Molecular Biology Institute, Univerisity of California, Los Angeles, CA 90095-1570 (USA), Fax: Int. code + (310) 206-7286, e-mail: [email protected]Search for more papers by this author Ottilie Zelenko, Ottilie Zelenko Department of Biological Chemistry, School of Medicine, Department of Chemistry and Biochemistry and Molecular Biology Institute, Univerisity of California, Los Angeles, CA 90095-1570 (USA), Fax: Int. code +(310) 206-7286, e-mail: [email protected]Search for more papers by this authorJames Gallagher, James Gallagher Department of Biological Chemistry, School of Medicine, Department of Chemistry and Biochemistry and Molecular Biology Institute, Univerisity of California, Los Angeles, CA 90095-1570 (USA), Fax: Int. code +(310) 206-7286, e-mail: [email protected]Search for more papers by this authorProf. David S. Sigman, Corresponding Author Prof. David S. Sigman Department of Biological Chemistry, School of Medicine, Department of Chemistry and Biochemistry and Molecular Biology Institute, Univerisity of California, Los Angeles, CA 90095-1570 (USA), Fax: Int. code +(310) 206-7286, e-mail: [email protected]Department of Biological Chemistry, School of Medicine, Department of Chemistry and Biochemistry and Molecular Biology Institute, Univerisity of California, Los Angeles, CA 90095-1570 (USA), Fax: Int. code + (310) 206-7286, e-mail: [email protected]Search for more papers by this author First published: January 7, 1997 https://doi.org/10.1002/anie.199727761Citations: 80 † This research was supported by U.S. Public Health Service (GM 21199). We would like to thank Ed Ruth of the Environmental Engineering Analytical Chemistry Laboratory, Department of Civil and Environmental Engineering, University of California, for assistance with the mass-spectrometry analyses. AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onEmailFacebookTwitterLinkedInRedditWechat Graphical Abstract C-1′H and not C-2′H is the initial site of oxidative cleavage of DNA with the chemical nuclease [Cu(phen)2]+/H2O2. This is the result of experiments with DNA containing C-1′-deuterated thymidine groups (the first step of the reaction sequence is shown below). If C-2′H is extracted in the first step, a one-electron oxidation and H/D migration should take place; there is no evidence of this. References 1 D. S. Sigman, A. Mazumder, D. M. Perrin, Chem. 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