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Alzheimer disease: Evidence for selective loss of cholinergic neurons in the nucleus basalis

1981; Wiley; Volume: 10; Issue: 2 Linguagem: Inglês

10.1002/ana.410100203

1531-8249

Peter J. Whitehouse, Donald L. Price, Arthur W. Clark, Joseph T. Coyle, Mahlon R. DeLong,

Neuroscience and Neuropharmacology Research

Abstract The nucleus basalis of Meynert provides diffuse cholinergic input to the neocortex. When compared with an age‐ and sex‐matched control, the nucleus basalis from a patient with Alzheimer disease demonstrated substantial reduction of neurons. Loss of this neuronal population may represent an anatomical correlate of the well‐documented cholinergic derangement in Alzheimer disease.