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Migration of Potent Drugs in Wet Granulations

1972; Elsevier BV; Volume: 61; Issue: 7 Linguagem: Inglês

10.1002/jps.2600610718

1520-6017

Imtiaz Chaudry, Robert E. King,

Analytical Chemistry and Chromatography

Sodium warfarin tablets prepared by a wet granulation method were shown to be unsatisfactory as to content uniformity due to the migration of the drug substance during the drying period. By using a TLC method, additives were selected which inhibited the migration of the drug substance. The use of these additives with sodium warfarin gave satisfactory tablets as to content uniformity when a wet granulation method was employed.