Serum deoxythymidine kinase in adult T-cell leukemia-lymphoma and its related disorders
1991; Elsevier BV; Volume: 15; Issue: 2-3 Linguagem: Inglês
10.1016/0145-2126(91)90089-c
ISSN1873-5835
AutoresNaoki Sadamori, Shuichi Ikeda, Toshihiro Yamaguchi, Mariko Mine, S Hakariya, Hirofumi Kinoshita, Kuniaki Hayashi, Tatsufumi Nakamura, Shigenobu Nagataki, Michito Ichimaru,
Tópico(s)Animal Disease Management and Epidemiology
ResumoSerum deoxythymidine kinase (TK) was measured in 15 patients with the acute type of adult T-cell leukemia (ATL), in 4 with chronic ATL, in 10 with lymphoma type ATL, in 9 with pre-ATL, in 11 with human T-cell leukemia virus type I (HTLV-I) associated with myelopathy (HAM) and in 19 HTLV-I carriers. All these patients were positive for anti-HTLV antibody. The level of TK in pretreatment serum was highest in acute ATL (15.6–1600 U/1, median 107 U/1). It was elevated in chronic ATL (5.4–55.0 U/1, median 37.6 U/1) and lymphoma ATL (6.8–316 U/1, median 16.8 U/1) but normal in pre-ATL(1.8–4.7 U/1, median 2.8 U/1), HAM (1.2–6.0 U/1, median 3.0 U/1) and HTLV-I carriers (1.1–4.6 U/1, median 2.3 U/1). Statistical examination revealed a significant difference between the levels of acute ATL and chronic ATL/lymphoma ATL. In the patients of this series, a close correlation between the level of TK and lactic dehydrogenase (LDH) was statistically present (p < 0.01). These facts indicate that TK level is a useful indicator of the aggressiveness of ATL cells.
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