Apoptosis, the Role of Oxidative Stress and the Example of Solar UV Radiation
1999; Wiley; Volume: 70; Issue: 4 Linguagem: Inglês
10.1111/j.1751-1097.1999.tb08239.x
ISSN1751-1097
AutoresCharareh Pourzand, Rex M. Tyrrell,
Tópico(s)Neutrophil, Myeloperoxidase and Oxidative Mechanisms
ResumoPhotochemistry and PhotobiologyVolume 70, Issue 4 p. 380-390 Free Access Apoptosis, the Role of Oxidative Stress and the Example of Solar UV Radiation Charareh Pourzand, Charareh Pourzand Department of Pharmacy & Pharmacology, University of Bath, Bath, UKSearch for more papers by this authorRex M. Tyrrell, Rex M. Tyrrell Department of Pharmacy & Pharmacology, University of Bath, Bath, UK *To whom correspondence should be addressed at: Department of Pharmacy and Pharmacology, University of Bath, Claverton Down, Bath BA2 7AY, UK. Fax: (44)-1225–826114; e-mail:[email protected]Search for more papers by this author Charareh Pourzand, Charareh Pourzand Department of Pharmacy & Pharmacology, University of Bath, Bath, UKSearch for more papers by this authorRex M. Tyrrell, Rex M. Tyrrell Department of Pharmacy & Pharmacology, University of Bath, Bath, UK *To whom correspondence should be addressed at: Department of Pharmacy and Pharmacology, University of Bath, Claverton Down, Bath BA2 7AY, UK. Fax: (44)-1225–826114; e-mail:[email protected]Search for more papers by this author First published: 02 January 2008 https://doi.org/10.1111/j.1751-1097.1999.tb08239.xCitations: 119 AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinkedInRedditWechat References 1 Tyrrell, R. M. (1991) UVA (320–380 nm) radiation as an oxidative stress. In Oxidative Stress: Oxidants and Antioxidants (Edited by H. Sies), pp. 57– 83. Academic Press, London . 2 Tyrrell, R. M. (1996) Activation of mammalian gene expression by the UV component of sunlight–from models to reality. BioEssays 18, 139– 148. 3 Gasparro, F. P., M. Mitchnick and J. F. Nash (1998) A review of sunscreen safety and efficacy. Photochem. Photobiol. 68, 243– 256. 4 Young, A. R. (1987) The sunburn cell. Photodermatology 4, 127– 134. 5 Ley, R. D. and L. A. Applegate (1985) Ultraviolet radiation-induced histopathologic changes in the skin of the marsupial Monodelphis domestica. II. Quantitative studies of the photo-reactivation of induced hyperplasia and sunburn cell formation. J. Invest. Dermatol. 85, 365– 367. 6 Weedon, D., J. Searle and J. F. Kerr (1979) Apoptosis. Its nature and implications for dermatopathology. Am. J. Derma-topathol. 1, 133– 144. 7 Ziegler, A., A. S. Jonasen, D. J. Leffell, J. A. Simon, H. W. Sharma, J. Kimmelman, L. Remington, T. Jacks and D. E. Brash (1994) Sunburn and p53 in the onset of skin cancer. Nature 372, 773– 776. 8 Barber L. A., D. F. Spandau, S. C. Rathman, R. C. Murphy, C. A. Johnson, S. W. Kelley, S. A. Hurwitz and J. B. Travers (1998) Expression of the platelet-activating factor receptor results in enhanced ultraviolet B radiation-induced apoptosis in a human epidermal cell line. J. Biol. Chem. 273, 18891– 18897. 9 Godar, D. E., S. A. Miller and D. P. Thomas (1994) Immediate and delayed apoptotic cell death mechanisms: UVA versus UVB and UVC radiation. Cell Death Differ. 1, 59– 66. 10 Danpure, H. J. and R. M. Tyrrell (1976) Oxygen dependence of near-UV (365 nm) lethality and the interaction of near-UV and X-rays in two mammalian cell lines. Photochem. Photobiol. 23, 171– 177. 11 Tyrrell, R. M., S. M. Keyse and E. C. Moreas (1991) Cellular defence against UVA (320–380 nm) and UVB (290–320 nm) radiations. In Photobiology (Edited by E. Riklis), pp. 861– 871. Plenum Press, New York . 12 Beauchamp, C. and I. Fridovich (1970) A mechanism for the production of ethylene from methional. The generation of the hydroxyl radical by xanthine oxidase. J. Biol. Chem. 245, 4641– 4646. 13 Badwey, J. A. and M. L. Karnovsky (1980) Active oxygen species and the functions of phagocytic leukocytes. Annu. Rev. Biochem. 49, 695– 726. 14 Punnonen, K., C. T. Jansen, A. Puntala and M. Ahotoupa (1991) Effects of in vitro UVA irradiation and PUVA treatment on membrane fatty acids and activities of antioxidant enzymes in human keratinocytes. J. Invest. Dermatol. 96, 255– 259. 15 Morliere, P., A. Moysan, R. Santus, G. Huppe, J.-C. Maziere and L. Ertret (1991) UVA-induced lipid peroxidation in cultured human fibroblasts. Biochim. Biophys. Acta 1084, 261– 268. 16 Vile, G. F. and R. M. Tyrrell (1995) UVA radiation-induced oxidative damage to lipids and proteins in vitro and in human skin fibroblasts is dependent on iron and singlet oxygen. Free Radical Biol. & Med. 18, 721– 730. 17 Vile, G. F., A. Tanew-Ilitschew and R. M. Tyrrell (1995) Activation of NF-KB in human skin fibroblasts by the oxidative stress generated by UVA radiation. Photochem. Photobiol. 62, 463– 468. 18 Wlaschek, M., K. Brivida, G. P. Stricklin, H. Sies and K. Scharffetter-Kochanek (1995) Singlet oxygen may mediate the ultraviolet A-induced synthesis of interstitial collagenase. J. Invest. Dermatol. 104, 194– 198. 19 Djavaheri-Mergny, M., J. L. Mergny, F. Bertrand, R. Santus, C. Maziere, L. Dubertret and J. C. Maziere (1996) Ultraviolet-A induces activation of AP-1 in cultered human keratinocytes. FEBS Lett. 384, 92– 96. 20 Wlaschek, M., J. Wenk, P. Brenneisen, K. Brivida, A. Schwarz, H. Sies and K. Scharffetter-Kochanek (1997) Singlet oxygen is an early intermediate in cytokine-dependent ultra-violet-A induction of interstitial collagenase in human dermal fibroblasts in vitro. FEBS Lett. 413, 239– 242. 21 Klotz, L. O., K. Brivida and H. Sies (1997) Singlet oxygen mediates the activation of JNK by UVA radiation in human skin fibroblasts. FEBS Lett. 408, 289– 291. 22 Keyse, S. M. and R. M. Tyrrell (1987) Both near ultraviolet radiation and the oxidizing agent hydrogen peroxide induce a 32 kDa stress protein in normal human skin fibroblasts. J. Biol. Chem. 262, 14821– 14825. 23 Keyse, S. M. and R. M. Tyrrell (1989) Heme oxygenase is the major 32 kDA stress protein induced in human skin fibroblasts by UVA radiation, hydrogen peroxide, and sodium arsenite. Proc. Natl. Acad. Sci. USA 86, 99– 103. 24 Stacker, R. (1990) Induction of haem oxygenase as a defense against oxidative stress. Free Radical Res. Commun. 9, 101– 112. 25 Saunders, E. L., M. D. Maines, M. J. Meredith and M. L. Freeman (1991) Enhancement of heme oxygenase-1 synthesis by glutathione depletion in Chinese hamster ovary cells. Arch. Biochem. Biophys. 288, 368– 373. 26 Jornot, L. and A. F. Junod (1993) Variable glutathione levels and expression of antioxidant enzymes in human endothelial cells. Am. J. Physiol. Lung Mol. Physiol. 264, L482– L489. 27 Tyrrell, R. M. and S. Basu-Modak (1994) Transient enhancement of heme oxygenase I mRNA accumulation: a marker of oxidative stress to eukaryotic cells. Methods Enzymol. 234, 224– 235. 28 Basu-Modak, S. and R. M. Tyrrell (1993) Singlet oxygen: a primary effector in the ultraviolet A/near visible light induction of the human heme oxygenase gene. Cancer Res. 53, 4505– 4510. 29 Gaboriau, F., N. Demoulins-Giacco, I. Tirache and P. Morliere (1995) Involvement of singlet oxygen in ultraviolet A-induced lipid peroxidation in cultured human skin fibroblasts. Arch. Dermatol. Res. 287, 338– 340. 30 Pourzand, C., R. D. Watkin, J. E. Brown and R. M. Tyrrell (1999) Ultraviolet A radiation induces immediate release of iron in human primary skin fibroblasts: the role of ferritin. Proc. Natl. Acad. Sci. USA 96, 6751– 6756. 31 Tyrrell, R. M. and M. Pidoux (1986) Endogenous glutathione protects human skin fibroblasts against the cytotoxic action of UVB, UVA and near-visible radiations. Photochem. Photobiol. 44, 561– 564. 32 Tyrrell, R. M. and M. Pidoux (1988) Correlation between endogenous glutathione content and sensitivity of cultured human skin cells to radiation at defined wavelengths in the solar UV range. Photochem. Photobiol. 41, 405– 412. 33 Thompson, C. B. (1995) Apoptosis in the pathogenesis and treatment of disease. Science 267, 1456– 1462. 34 Kerr, J. F. R., A. H. Wyllie and A. R. Currie (1972) Apoptosis: a basic biological phenomenon with wide-ranging implications in tissue kinetics. Br. J. Cancer 26, 239– 257. 35 Wyllie, A. H. (1980) Glucocorticoid-induced thymocyte apoptosis is associated with endogenous endonuclease activation. Nature 284, 555– 556. 36 Newmeyer, D. D., D. M. Farschon and J. C. Reed (1994) Cell-free apoptosis in Xenopus egg extracts: inhibition by Bcl-2 and requirement for an organelle fraction enriched in mitochondria. Cell 79, 353– 364. 37 Ankarcrona, M., J. M. Dypbukt, E. Bonfoco, B. Zhivotovsky, S. Orrenius, S. A. Lipton and P. Nicotera (1995) Glutamate-induced neuronal death: a succession of necrosis or apoptosis depending on mitochondrial function. Neuron 15, 961– 973. 38 Zamzami, N., P. Marchetti, M. Castedo, C. Zanin, J.-L. Vays-siere, P. X. Petit and G. Kroemer (1995) Reduction in mitochondrial potential constitutes an early irreversible step of programmed lymphocyte death in vivo. J. Exp. Med. 181, 1661– 1672. 39 Zamzami, N., P. Marchetti, M. Castedo, D. Decaudin, A. Macho, T. Hirsch, S. A. Susin, P. X. Petit, B. Mignotte and G. Kroemer (1995) Sequential reduction of mitochondrial transmembrane potential and generation of reactive oxygen species in early programmed cell death. J. Exp. Med. 182, 367– 377. 40 Kroemer, G. (1997) Mitochondrial implication in apoptosis. Towards an endosymbiont hypothesis of apoptosis evolution. Cell Death Differ. 4, 443– 456. 41 Cai, J., J. Yang and D. P. Jones (1998) Mitochondrial control of apoptosis: the role of cytochrome c. Biochim. Biophys. Acta 1366, 139– 149. 42 Mitchell, P. and J. Moyle (1965) Stoichiometry of proton trans-location through the respiratory chain and adenosine triphosphate systems of rat liver mitochondria. Nature 208, 147– 151. 43 Azzone, G. F. and S. Massari (1973) Active transport and binding in mitochondria. Biochim. Biophys. Acta 301, 195– 226. 44 Lee C. P. (1995) Biochemical studies of isolated mitochondria from normal and diseased tissues. Biochim. Biophys. Acta 1271, 21– 28. 45 Rosser, B. G. and G. J. Gores (1995) Liver cell necrosis: cellular mechanisms and clinical implications. Gastroenterology 108, 252– 275. 46 Liu, X., C. N. Kim, J. Yang, R. Jemmerson and X. Wang (1996) Induction of the apoptotic program in cell-free extracts: requirement for dATP and cytochrome c. Cell 86, 147– 157. 47 Susin, S. A., N. Zamzami, M. Castedo, T. Hirsch, P. Marchetti, A. Macho, E. Daugas, M. Geukens and G. Kroemer (1996) Bcl-2 inhibits the mitochondrial release of an apoptogenic protease. J. Exp. Med. 184, 1331– 1341. 48 Alnemri, E. S., D. J. Livingston, D. W. Nicholson, G. Salves-en, N. A. Thornberry, W. W. Wong and J. Yuan (1996) Human ICE/CED3 protease nomenclature. Cell 87, 171. 49 Stennicke, H. R. and G. S. Salvesen (1998) Properties of the caspases. Biochim. Biophys. Acta 1387, 17– 31. 50 Liu, X., H. Zou, C. Slaughter and X. Wang (1997) DFF, a heterodimeric protein that functions downstream of caspase-3 to trigger DNA fragmentation during apoptosis. Cell 89, 175– 184. 51 Alnemri, E. S. (1997) Mammalian cell death proteases: a family of highly conserved aspartate specific cysteine proteases. J. Cell. Biochem. 64, 33– 42. 52 Bossy-Wetzel, E., D. D. Newmeyer and D. R. Green (1998) Mitochondrial cytochrome c release in apoptosis occurs upstream of DEVD-specific caspase activation and independently of mitochondrial transmembrane depolarization. EMBO J. 17, 37– 49. 53 Deckwerth, T. L. and E. M. Johnson, Jr. (1993) Temporal analysis of events associated with programmed cell death (apoptosis) of sympathetic neurons deprived of nerve growth factor. J. Cell Biol. 123, 1207– 1222. 54 Vayssiere, J.-L., P. X. Petit, Y. Risler and B. Mignotte (1994) Commitment to apoptosis is associated with changes in mitochondrial biogenesis and activity in cell lines conditionally immortalized with simian virus 40. Proc. Natl. Acad. Sci. USA 91, 11752– 11756. 55 Kroemer, G., N. Zamzami and S. A. Susin (1997) Mitochondrial control of apoptosis. Immunol. Today 18, 44– 51. 56 Zoratti, M. and I. Szabo (1995) The mitochondrial permeability transition. Biochim. Biophys. Acta 1241, 139– 179. 57 Bernardi, P. and V. Petronilli (1996) The permeability transition pore as a mitochondrial calcium release channel; a critical appraisal. J. Bioenerg. Biomembr. 28, 129– 136. 58 Zamzami, N., S. A. Susin, P. Marchetti, T. Hirsch, I. Gomez-Monterrey, M. Castedo and G. Kroemer (1996) Mitochondrial control of nuclear apoptosis. J. Exp. Med. 183, 1533– 1544. 59 Zamzami, N., P. Marchetti, M. Castedo, T. Hirsch, S. A. Susin, B. Masse and G. Kroemer (1996) Inhibitors of permeability transition interfere with the disruption of the mitochondrial membrane potential during apoptosis. FEBS Lett. 384, 153– 157. 60 Susin, S. A., N. Zamzami and G. Kroemer (1998) Mitochondria as regulators of apoptosis: doubt no more. Biochim. Biophys. Acta 1366, 151– 165. 61 Ichas, F., L. S. Jouaville and J.-P. Mazat (1997) Mitochondria are excitable organelles capable of generating and conveying electrical and calcium signals. Cell 89, 1145– 1153. 62 Martin, S. J., C. P. M. Reutelingsperger, A. J. McGahon, J. A. Rader, R. C. A. A. van Schie, D. M. LaFace and D. R. Green (1995) Early redistribution of plasma membrane phosphatidyl-serine is a general feature of apoptosis regardless of the initiating stimulus: inhibition by overexpression of Bcl-2 and Abl. J. Exp. Med. 182, 1545– 1556. 63 Hirsch, T., I. Marzo and G. Kroemer (1997) Role of mitochondrial permeability transition pore in apoptosis. Biosci. Rep. 17, 67– 76. 64 Marchetti, P., D. Decaudin, A. Macho, N. Zamzami, T. Hirsch, S. A. Susin and G. Kroemer (1997) Redox regulation of apoptosis: impact of thiol oxidation status on mitochondrial function. Eur. J. Immunol. 27, 289– 296. 65 Backway, K. L., E. A. McCulloh, S. Chow and D. W. Hedley (1997) Relationship between the mitochondrial permeability transition and oxidative stress during ara-C toxicity. Cancer Res. 57, 2446– 2451. 66 Petit, P. X., S. A. Susin, N. Zamzami, B. Mignotte and G. Kroemer (1996) Mitochondria and programmed cell death: back to the future. FEBS Lett. 396, 7– 13. 67 Kluck, R. M., E. Bossy-Wetzel, D. R. Green and D. D. Newmeyer (1997) The release of cytochrome c from mitochondria: a primary site for Bcl-2 regulation of apoptosis. Science 275, 1132– 1136. 68 Yang, J., X. Liu, K., Bhalla, C. N. Kim, A. M. Ibrado, J. Cai, T. I. Peng, D. P. Jones and X. Wang (1997) Prevention of apoptosis by Bcl-2: release of cytochrome c from mitochondria blocked. Science 275, 1126– 1132. 69 Cai, J. and D. P. Jones (1998) Superoxide in apoptosis. Mitochondrial generation triggered by cytochrome c loss. J. Biol. Chem. 273, 11401– 11404. 70 Susin, S. A., N. Zamzami, M. Castedo, E. Daugas, H.-G. Wang, S. Geley, F. Fassy, J. C. Reed and G. Kroemer (1997) The central executioner of apoptosis: multiple connections between protease activation and mitochondria in Fas/Apo-1/CD-95 and ceramide-induced apoptosis. J. Exp. Med. 186, 25– 37. 71 Farrow, S. N. and R. Brown (1996) New members of the Bcl-2 family and their protein partners. Curr. Opin. Genet. Dev. 6, 45– 49. 72 Kroemer, G. (1997) The proto-oncogene Bcl-2 and its role in regulating apoptosis. Nature Med. 3, 614– 620. 73 Oltvai, Z. N., C. L. Milliman and S. J. Korsmeyer (1993) Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programmed cell death. Cell 74, 609– 619. 74 Muchmore, S. W., M. Sattler, H. Liang, R. P. Meadows, J. E. Harlan, H. S. Yoon, D. Nettesheim, B. S. Chang, C. B. Thompson, S. L. Wong, S. L. Ng and S. W. Fesik (1996) X-ray and NMR structure of human Bcl-xL, an inhibitor of programmed cell death. Nature 381, 335– 341. 75 Hockenbery, D., G. Nunez, C. Milliman, R. D. Screiber and S. J. Korsmeyer (1990) Bcl-2 is an inner mitochondrial membrane protein that blocks programmed cell death. Nature 348, 334– 336. 76 Krajewski, S., S. Tanaka, S. Takayama, M. J. Schibler, W. Fenton and J. C. Reed (1993) Investigation of the subcellular distribution of the bcl-2 oncoprotein: residence in the nuclear envelope, endoplasmic reticulum and outer mitochondrial membranes. Cancer Res. 53, 4701– 4714. 77 De Jong, D., F. A. Prins, D. Y. Mason, J. C. Reed, G. B. Van Ommen and P. M. Kluin (1994) Subcellular localization of the bcl-2 protein in malignant and normal lymphoid cells. Cancer Res. 54, 256– 260. 78 Nguyen, M., D. G. Millar, V. W. Yong, S. J. Korsmeyer and G. C. Shore (1993) Targeting of Bcl-2 to the mitochondrial outer membrane by a COOH-terminal signal anchor sequence. J. Biol. Chem. 268, 25265– 25268. 79 Goping, I. S., A. Gross, J. N. Lavoie, M. Nguyen, R. Jemmerson, K. Roth, S. J. Korsmeyer and G. C. Shore (1998) Regulated targeting of BAX to mitochondria. J. Cell Biol. 143, 207– 215. 80 Hsu, Y.-T., K. G. Wolter and R. J. Youle (1997) Cytosol-to-membrane redistribution of Bax and Bcl-2 during apoptosis. Proc. Natl. Acad. Sci. USA 94, 3668– 3672. 81 Wolter, K. G., Y.-T. Hsu, C. L. Smith, A. Nechushtan, X.-G. Xi and R. J. Youle (1997) Movement of Bax from cytosol to mitochondria during apoptosis. J. Cell Biol. 139, 1281– 1292. 82 Gross, A., J. Jockel, M. C. Wei and S. J. Korsmeyer (1998) Enforced dimerization of BAX results in its translocation, mitochondrial dysfunction and apoptosis. EMBO J. 17, 3878– 3885. 83 Martinou, J. C., R. Eskes, S. Desagher, E. Andre, A. Osen, S. Montessuit, I. Martinou, S. Lauper, A. Hockman and B. An-tonsson (1998) Bax induces cytochrome-c release from mitochondria independently from opening of the permeability transition pore. International Conference on Life and Death of a Cell. Fribourg, Switzerland, 17–18 September 1998, Abstracts. Anticancer Res. 18, 4517– 4563. 84 Hennet, T., G. Bertoni, C. Richter and E. Peterhans (1993) Expression of BCL-2 protein enhances the survival of mouse fibrosarcoid cells in tumor necrosis factor-mediated cytotoxicity. Cancer Res. 53, 1456– 1460. 85 Shimizu, S., Y. Eguchi, W. Kamiike, H. Matsuda and Y. Tsu-jimoto (1996) Bcl-2 expression prevents activation of the ICE protease cascade. Oncogene 12, 2251– 2257. 86 Shimizu, S., Y. Eguchi, W. Kamiike, S. Wagui, Y. Uchiyama, H. Mtsuda and Y. Tsujimoto (1996) Bcl-2 blocks loss of mitochondrial membrane potential while ICE inhibitors act at a different step during inhibition of death induced by respiratory chain inhibitors. Oncogene 13, 21– 29. 87 Boise, L. H. and C. B. Thompson (1997) Bcl-x, can inhibit apoptosis in cells that have undergone Fas-induced protease activation. Proc. Natl. Acad. Sci. USA 94, 3759– 3764. 88 Nicolli, A., E. Basso, V. Petronilli, R. M. Wenger and P. Ber-nardi (1996) Interactions by cyclophilin with mitochondrial inner membrane and regulation of the permeability transition pore, a cyclosporine A-sensitive channel. J. Biol. Chem. 271, 2185– 2192. 89 Reed, J. C. (1997) Double identity for proteins of the Bcl-2 family. Nature 387, 773– 776. 90 Jurgensmeier, J. M., Z. Xie, Q. Deveraux, L. Ellerby, D. Bredesen and J. C. Reed (1998) Bax directly induces release of cytochrome c from isolated mitochondria. Proc. Natl. Acad. Sci. USA 95, 4997– 5002. 91 Xiang, J., D. T. Chao and S. J. Korsmeyer (1996) BAX-in-duced cell death may not require interleukin 1 B-converting enzyme-like proteases. Proc. Natl. Acad. Sci. USA 93, 14559– 14563. 92 McCarthy, N. J., M. K. Whyte, C. S. Gilbert and G. I. Evan (1997) inhibition of Ced-3/ICE-related proteases does not prevent cell death induced by oncogenes, DNA damage, or Bcl-2 homologue Bak. J. Cell Biol. 136, 215– 227. 93 Minn, A. J., P. Velez, S. L. Schendel, H. Liang, S. W. Fesik, M. Fill and C. B. Thompson (1997) Bcl-x(L) forms an ion channel in synthetic lipid membranes. Nature 385, 353– 357. 94 Schendel, S. L., Z. Xie, M. O. Montal, S. Matsuyama, M. Montal and J. C. Reed (1997) Channel formation by antiapop-totic protein Bcl-2. Proc. Natl. Acad. Sci. USA 94, 5113– 5118. 95 Antonsson, B., F. Conti, A. Ciavatta, S. Montessuit, S. Lewis, I. Martinou, L. Bernasconi, A. Bernard, J. J. Mermod, G. Maz-zei, K. Maundrell, F. Gambale, R. Sadoul and J. C. Martinou (1997) Inhibition of Bax channel-forming activity by Bcl-2. Science 277, 370– 372. 96 Schlesinger, P. H., A. Gross, X.-M. Yin, K. Yamamoto, M. Saito, G. Waksman and S. J. Korsmeyer (1997) Comparison of the ion channel characteristics of proapoptotic BAX and antiapoptotic Bcl-2. Proc. Natl. Acad. Sci. USA 94, 11357– 11362. 97 Marzo, I., C. Brenner, N. Zamzami, J. M. Jurgensmeier, S. A. Susin, H. L. Vieira, M. C. Prevost, Z. Xie, S. Matsuyama, J. C. Reed and G. Kroemer (1998) Bax and adenine nucleotide translocator cooperate in the mitochondrial control of apoptosis. Science 281, 2027– 2031. 98 Zamzami, N., C. Brenner, I. Marzo, S. A. Susin and G. Kroemer (1998) Subcellular and submitochondrial mode of action of Bcl-2-like oncoproteins. Oncogene 16, 2265– 2282. 99 Buttke, T. M. and P. A. Sandstrom (1994) Oxidative stress as a mediator of apoptosis. Immunol. Today 15, 7– 10. 100 Jacobson, M. D. (1996) Reactive oxygen species and programmed cell death. Trends Biochem. Sci. 21, 83– 86. 101 Strasser, A., A. W. Harris and S. Croy (1991) bcl-2 transgene inhibits T cell death and perturbs thymic self-censorship. Cell 67, 889– 899. 102 Halliwell, B. and J. M. C. Gutteridge (1989) Free Radicals in Biology and Medicine, 2nd ed. Clarendon Press, Oxford , England . 103 Lennon, S. V., S. J. Martin and T. G. Cotter (1991) Dose-dependent induction of apoptosis in human tumor cell lines by widely diverging stimuli. Cell Prolif. 24, 203– 214. 104 Gardner, A. M., F. H. Xu, C. Fady, F. J. Jacoby, D. C. Duffey, Y. Tu and A. Lichtenstein (1997) Apoptotic vs. nonapoptotic cytotoxicity induced by hydrogen peroxide. Free Radical Biol. & Med. 22, 73– 83. 105 Sato, N., S. Iwata, K. Nakamura, T. Hori, K. Mori and J. Yodoi (1995) Thiol-mediated redox regulation of apoptosis. Possible roles of cellular thiols other than glutathione in T cell apoptosis. J. Immunol. 154, 3194– 3203. 106 Bustamante, J., B. A. Tovar, G. Monteo and A. Boveris (1997) Early redox changes during rat thymocyte apoptosis. Arch. Biochem. Biophys. 337, 121– 128. 107 Sun, X. and D. Ross (1996) Quinone-induced apoptosis in human colon adenocarcinoma cells via DT-diaphorase mediated bioactivation. Chem.-Biol. Interact. 100, 267– 276. 108 Larrick, J. W. and S. C. Wright (1990) Cytotoxic mechanism of tumor necrosis factor alpha. FASEB J. 4, 3215– 3223. 109 Wang, J. H., H. P. Redmond, R. W. Watson and D. Bouchier-Hayes (1997) Induction of human endothelial cell apoptosis requires both heat-shock and oxidative stress responses. Am. J. Physiol. 272, C1543– C1551. 110 Garcia-Ruiz, C., A. Colell, M. Man, A. Morales and J. C. Fernandez-Checa (1997) Direct effect of ceramide on the mitochondrial electron transport chain leads to generation of reactive oxygen species. Role of mitochondrial glutathione. J. Biol. Chem. 272, 11369– 11377. 111 Atabay, C., C. M. Cagnoli, E. Kharlamov, M. D. Ikonomovic and H. Nanev (1996) Removal of serum from primary cultures of cerebellar granule neurons induces oxidative stress and DNA fragmentation: protection with antioxidants and gluta-mate receptor antagonists. J. Neurosci. Res. 43, 465– 475. 112 Slater, A. F., C. Stefan, I. Nobel, D. J. van den Dobbesteen and S. Orrenius (1995) Signalling mechanisms and oxidative stress in apoptosis. Toxicol. Lett. 82–83, 149– 153. 113 Mayer M. and M. Noble (1994) N-acetyl-L-cysteine is a plu-ripotent protector against cell death and enhancer of trophic factor-mediated cell survival in vitro. Proc. Natl. Acad. Sci. USA 91, 7496– 7500. 114 Iwata, S., T. Hon, N. Sato, K. Hirota, T. Sasada, A. Mitsui, T. Hirakaw and J. Yodoi (1997) Adult T cell leukemia (ATL)-derived factor/human thioredoxin prevents apoptosis of lymphoid cells induced by L-cystine and glutathione depletion: possible involvement of thiol-mediated redox regulation in apoptosis caused by oxidant state. J. Immunol. 158, 3108– 3117. 115 Wong, G. H., J. H. Elwell, L. W. Oberley and D. R. Goeddel (1989) Manganous superoxide dismutase is essential for cellular resistance to cytotoxicity of tumor necrosis factor. Cell 58, 923– 931. 116 Zhong, L. T., T. Sarafian, D. J. Kane, A. C. Charles, S. P., Mash, R. H. Edwards and D. E. Bredesen (1993) bcl-2 inhibits death of central neural cells induced by multiple agents. Proc. Natl. Acad. Sci. USA 90, 4533– 4537. 117 Skulachev, V. P. (1996) Why are mitochondria involved in apoptosis? Permeability transition pores and apoptosis as selective mechanisms to eliminate superoxide-producing mitochondria and cells. FEBS Lett. 397, 7– 10. 118 Lenaz, G. (1998) Role of mitochondria in oxidative stress and ageing. Biochim. Biophys. Acta 1366, 53– 67. 119 Robinson, N. C. (1993) Functional binding of cardiolipin to cytochrome c oxidase. J. Bioenerg. Biomembr. 25, 153– 163. 120 Smith, M. W., Y. Collan, M. W. Kahng and B. F. Trump (1980) Changes in mitochondrial lipids of rat kidney during ischemia. Biochim. Biophys. Acta 618, 192– 201. 121 Okayasu, T., M. T. Curtis and J. L. Farber (1985) Structural alterations of the inner mitochondrial membrane in ischemic liver cell injury. Arch. Biochem. Biophys. 236, 638– 645. 122 Laganiere, S. and B. P. Yu (1993) Modulation of membrane phospholipid fatty acid composition by age and food restriction. Gerontology 39, 7– 18. 123 Forsmark-Andree, P., C. P. Lee, G. Dallner and L. Ernster (1997) Lipid peroxidation and changes in the ubiquinone content and the respiratory chain enzymes of submitochondrial particles. Free Radical Biol. & Med. 22, 391– 400. 124 Lippe, G., M. Comelli, F. Mazzilis, F. Dabbeni-Sala and I. Mavelli (1991) The inactivation of mitochondrial Fl ATPase by H2O2 is mediated by iron ions not tightly bound in the protein. Biochem. Biophys. Res. Commun. 181, 764– 770. 125 Forsmak-Andree, P., G. Dallner and L. Ernster (1995) Endogenous ubiquinol prevents protein modification accompanying lipid peroxidation. Free Radical Biol. & Med. 19, 749– 757. 126 Griffiths, E. J. and A. P. Halestrap (1995) Mitochondrial nonspecific pores remain closed during cardiac ischaemia, but open upon reperfusion. Biochem. J. 307, 93– 98. 127 Petronilli, V., A. Nicolli, P. Costantini, R. Colonna and P. Ber-bardi (1994) Regulation of the permeability transition pore, a voltage-dependent mitochondrial channel inhibited by cyclosporin A. Biochim. Biophys. Acta 1187, 255– 259. 128 Costantini, P., B. V. Chernyak, V. Petronilli and P. Bernardi (1996) Modulation of the mitochondrial permeability transition pore by pyrimidine nucleotides and dithiol oxidation at two separate sites. J. Biol. Chem. 271, 6746– 6751. 129 Petronilli, V., P. Costantini, L. Scorrano, R. Colonna, S. Pas-samonti and P. Bernardi (1994) The voltage sensor of the mitochondrial permeability transition pore is tuned by the oxidation-reduction state of vicinal thiols. Increase of the gating potential by oxidants and its reversal by reducing agents. J. Biol. Chem. 269, 16638– 16642. 130 Macho, A., T. Hirsch, I. Marzo, P. Marcetti, B. Dallaporta, S. A. Susin, N. Zamzami and G. Kroemer (1997) GSH depletion is an early and calcium elevation is a late event of thymocyte apoptosis. J. Immunol. 158, 4612– 4619. 131 Nieminen, A. L., A. M. Byrne, B. Herman and J. J. Lemasters (1997) Mitochondrial permeability transition in hepatocytes induced by t-BuOOH: NAD(P)H and reactive oxygen species. Am. J. Physiol. 272, C1286– C1294. 132 Pourzand, C., G. Rossier, O. Reelfs, C. Borner and R. M. Tyrrell (1997) The overexpression of Bcl-2 inhibits UVA-medi-ated immediate apoptosis in rat 6 fibroblasts: evidence for the involvement of Bcl-2 as an antioxidant. Cancer Res. 57, 1405– 1411. 133 Hockenbery, D. M., Z. N. Oltvai, X.-M. Yin, C. L. Milliman and S. J. Korsmeyer (1993) Bcl-2 functions in an antioxidant pathway to prevent apoptosis. Cell 75, 241– 251. 134 Kane, D. J., T. A. Sarafian, R. Anton, H. Hahn, E. B. Gralla, J. S. Valentine, T. Ord and D. E. Bredesen (1993) Bcl-2 inhibition of neural death: decreased generation of reactive oxygen species. Science 262, 1274– 1277. 135 Godar, D. E. and A. D. Lucas (1995) Spectral dependence of UV-induced immediate and delayed apoptosis: the role of membrane and DNA damage. Photochem. Photobiol. 62, 108– 113. 136 Bose, B., S. Argaval and S. N. Chatterjee (1989) UV-A induced lipid peroxidation in liposomal membrane. Radial. Environ. Biophys. 28, 59– 65. 137 Bose, B., S. Argaval and S. N. Chatterjee (1990) Membrane lipid peroxidation by UV-A: mechanism and implications. Bio-technol. Appl. Biochem. 12, 557– 561. 138 Lithgow, T., R. Van Driel, J. F. Bertram and A. Strasser. (1994) The protein product of the oncogene bcl-2 is a component of the nuclear envelope, the endoplasmic reticulum, and the outer mitochondrial membrane. Cell Growth Differ. 5, 411– 417. 139 Morita, A., T. Werfel, H. Stege, C. Ahrens, K. Karmann, M. Grewe, S. Grether-Beck, T. Rizicka, A. Kapp, L. O. Klotz, H. Sies and J. Krutmann (1997) Evidence that singlet oxygen-induced human T helper cell apoptosis is the basic mechanism of ultraviolet-A radiation phototherapy. J. Exp. Med. 186, 1763– 1768. 140 Godar, D. E. (1999) UVA1 radiation triggers two different final apoptotic pathways. J. Invest. Dermatol. 112, 3– 12. 141 Tada-Oikawa, S., S. Oikawa and S. Kawanishi (1998) Role of ultraviolet A-induced oxidative DNA damage in apoptosis via loss of mitochondrial membrane potential and caspase-3 activation. Biochem. Biophys. Res. Commun. 247, 696– 696. 142 Kvam, E. and R. M. Tyrrell (1997) Induction of oxidative DNA damage in human skin cells by UV and near visible radiation. Carcinogenesis 18, 2379– 2384. 143 Aoshima, H., T. Satoh, N. Sakai, M. Yamada, Y. Enokido, T. Ikeuchi and H. Hatanaka (1997) Generation of free radicals during lipid hydroperoxide-triggered apoptosis in PC12h cells. Biochim. Biophys. Acta 1345, 35– 42. 144 Kovar, J., L. L. Stunz, B. C. Stewart, K. Kriegerbeckova, R. F. Ashman and J. D. Kemp (1997) Direct evidence that iron deprivation induces apoptosis in murine lymphoma 38C13. Pathobiology 65, 61– 68. 145 Haq, R. U., J. P. Werely and C. R. Chitambar (1995) Induction of apoptosis by iron deprivation in human leukemic CCRF-CEM cells. Exp. Hematol. 23, 428– 432. 146 Leardi, A., M. Caraglia, C. Selleri, S. Pepe, C. Pizzi, R. Notaro, A. Fabbrocini, S. De Lorenzo, M. Mujsico, A. Abbruzzese, A. R. Bianco and P. Tagliaferri (1998) Desferrioxamine increases iron depletion and apoptosis induced by ara-C of human myeloid leukaemic cells. Br. J. Haematol. 102, 746– 752. 147 Jelaska, A. and J. H. Korn (1998) Anti-Fas induces apoptosis and proliferation in human dermal fibroblasts: differences between foreskin and adult fibroblasts. J. Cell. Physiol. 175, 19– 29. 148 Shindo, Y. and T. Hashimoto (1998) Ultraviolet B-induced cell death in four cutaneous cell lines exhibiting different enzymatic antioxidant defences: involvement of apoptosis. J. Dermatol. Sci. 17, 140– 150. 149 Majima, H. J., T. D. Oberley, K. Furukawa, M. P. Mattson, H. C. Yen, L. I. Szweda and D. K. St. Clair (1998) Prevention of mitochondrial injury by manganese superoxide dismutase reveals a primary mechanism for alkaline-induced cell death. J. Biol. Chem. 273, 8217– 8224. 150 Bauerle, P. A. and T. Henkel (1994) Function and activation of NF-kappa B in the immune system. Annu. Rev. Immunol. 12, 141– 179. 151 Malinin, N. L., M. P. Boldin, A. V. Kovalenko and D. Wallach (1997) MAP3K-related kinase in NF-kappaB induction by TNF, CD95 and IL-1. Nature 385, 540– 544. 152 Wang, C. Y., M. W. Mayo, R. G. Korneluk, D. V. Goeddel and A. S. Baldwin, Jr. (1998) NF-kappaB antiapoptotic: induction of TRAF1 and TRAF2 and c-IAPl and C-IAP2 to suppress caspase-8 activation. Science 281, 1680– 1683. 153 de Moissac, D., S. Mustapha, A. H. Greenberg and L. A. Kir-shenbaum (1998) Bcl-2 activates the transcription factor NFkappaB through the degradation of the cytoplasmic inhibitor IkappaBalpha. J. Biol. Chem. 273, 23946– 23951. 154 Klefstrom, J., E. Arighi, T. Littlewood, M. Jaattela, E. Saksela, G. I. Evan and K. Alitalo (1997) Induction of TNF-sensitive cellular phenotype by c-Myc involves p53 and impaired NF-kappaB activation. EMBO J. 16, 7382– 7392. 155 Cotton, J. and D. F. Spandau (1997) Ultraviolet B-radiation dose influences the induction of apoptosis and p53 in human keratinocytes. Radial Res. 147, 148– 155. 156 Schwarz, A., R. Bhardwaj, Y. Aragane, K. Mahnke, H. Rie-mann, D. Metze, T. A. Luger and T. Schwarz (1995) Ultra-vioIet-B-induced apoptosis of keratinocytes: evidence for partial involvement of tumor necrosis factor-a in the formation of sunburn cells. J. Invest. Dermatol. 104, 922– 927. 157 Gorman, A., A. McGowan and T. G. Cotter (1997) Role of peroxide and superoxide anion during tumour cell apoptosis. FEBS Lett. 404, 27– 33. Citing Literature Volume70, Issue4October 1999Pages 380-390 ReferencesRelatedInformation
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