Pharmacology of Systemic Antifungal Agents
2006; Oxford University Press; Volume: 43; Issue: Supplement_1 Linguagem: Inglês
10.1086/504492
ISSN1537-6591
AutoresElizabeth S. Dodds Ashley, Russell E. Lewis, James S. Lewis, Craig A. Martin, David R. Andes,
Tópico(s)Synthesis and Biological Evaluation
ResumoTraditionally, many invasive fungal infections were associated with a poor prognosis, because effective therapeutic options were limited. The recent development of new antifungal agents has significantly contributed to the successful treatment of fungal diseases. These drugs offer novel mechanisms of action and expanded spectrums of activity over traditional treatment options. However, with these new agents comes the need for increased awareness of the potential interactions and toxicities associated with these drugs. Therefore, an understanding of the pharmacokinetic and pharmacodynamic properties of the classes of antifungal compounds is vital for the effective management of invasive fungal infections. This review provides a summary of the pharmacologic principles involved in treatment of fungal diseases.
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