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Total pancreatectomy in toads: Effect of hypophysectomy and glucagon

1964; Elsevier BV; Volume: 4; Issue: 3 Linguagem: Inglês

10.1016/0016-6480(64)90020-6

1095-6840

J. C. Penhos, Nelly Lavintman,

Pancreatitis Pathology and Treatment

Abstract Totally pancreatectomized toads ( Bufo arenarum Hensel) had an average survival time of 9 days with a loss of body weight of 31%. Hypophysectomy performed before pancreatectomy increased the survival time to 14 days with a loss of body weight of 18%. Hyperglycemia produced by pancreatectomy (320 mg/100 ml) was markedly decreased by hypophysectomy (63 mg/100 ml). Liver glycogen decreased only in hypophysectomized and in hypophysectomized-pancreatectomized toads; no changes were observed in heart or muscle glycogen, in the different groups, during the experiments. Glucagon produced its characteristic hyperglycemic action more intensely and quickly when given intravenously than when given subcutaneously. Pancreatectomized and hypophysectomized-pancreatectomized toads were more sensitive to glucagon hyperglycemia than were the control or the hypophysectomized animals. Glucagon did not produce hyperglycemia in hepatectomized toads.