Primary Breast Lymphoma: Results of a Controlled Clinical Trial
2005; Karger Publishers; Volume: 69; Issue: 3 Linguagem: Inglês
10.1159/000088333
ISSN1423-0232
AutoresAgustín Avilés, Serafín Delgado, M. Jesús Nambo, Natividad Neri, Edgar Murillo, Sergio Cleto,
Tópico(s)CNS Lymphoma Diagnosis and Treatment
Resumo<i>Objectives:</i> To assess the efficacy and toxicity of the most employed therapeutic approaches in the treatment of primary breast lymphoma (PBL). <i>Methods:</i> Ninety-six patients with PBL in the early stage (I or II) were enrolled to receive radiotherapy (45 Gy); chemotherapy (six cycles of cyclophosphamide, doxorubicin, vincristine and prednisone (CHOP), every 21 days), or combined therapy. <i>Results:</i> Complete response was achieved in 20 of 30 patients treated with radiotherapy, 19 of 32 who were treated with chemotherapy and 30 of 34 in the combined arm (p < 0.01). Actuarial curves at 10 years showed that event-free survival was 50, 57 and 83%, respectively (p < 0.01). Actuarial curves for overall survival were 50, 50 and 76% (p < 0.01), respectively. The most common site of relapse was the central nervous system. Acute toxicity was mild. Until now, no second neoplasm or acute leukemia has been observed. <i>Conclusions:</i> In our study combined therapy is the best treatment in this special setting of patients; with improvement in event-free survival and overall survival without acute or severe late side effects. Prophylaxis to the central nervous system will be considered in the initial treatment to improve outcome.
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