Enantioselective Total Synthesis of (−)‐Lansai B and (+)‐Nocardioazines A and B
2014; Wiley; Volume: 53; Issue: 24 Linguagem: Inglês
10.1002/anie.201402571
ISSN1521-3773
AutoresHaoxuan Wang, Sarah E. Reisman,
Tópico(s)Advanced Synthetic Organic Chemistry
ResumoAbstract The concise total syntheses of the bis(pyrroloindolines) (−)‐lansai B and (+)‐ nocardioazines A and B are reported. The key pyrroloindoline building blocks are rapidly prepared by enantioselective formal [3+2] cycloaddition reactions. The macrocycle of (+)‐nocardioazine A is constructed by an unusual intramolecular diketopiperazine formation.
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