The absolute configuration of a hypolipidemic 1-aryl tetralin, nafenopin
1970; Elsevier BV; Volume: 26; Issue: 23 Linguagem: Inglês
10.1016/s0040-4020(01)98751-4
ISSN1464-5416
AutoresW. L. Bencze, Biruta Kisis, R. T. Puckett, N. FINCH,
Tópico(s)Analytical Chemistry and Chromatography
ResumoA new hypolipidemic agent, 2-methyl-2-[p-(1,2,3,4-tetrahydro-1-napthyl)phenoxy] propionic acid, has been resolved. The absolute configurations of the enantiomers have been established by (a) ORD correlation with the lignans (b) application of the ORD skewed styrene rule to the derived dehydro compound and (c) the Bijvoet X-ray procedure on an iodo derivative.
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