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BIBTEX RIS

Photoinduced Nitric Oxide and Singlet Oxygen Release from ZnPC Liposome Vehicle Associated with the Nitrosyl Ruthenium Complex: Synergistic Effects in Photodynamic Therapy Application

2008; Wiley; Volume: 85; Issue: 3 Linguagem: Inglês

10.1111/j.1751-1097.2008.00481.x

ISSN

1751-1097

Autores

Daniela Silva Maranho, Renata Galvão de Lima, Fernando Lucas Primo, Roberto Santana da Silva, Antônio Cláudio Tedesco,

Tópico(s)

Porphyrin and Phthalocyanine Chemistry

Resumo

Under continuous photolysis at 675 nm, liposomal zinc phthalocyanine associated with nitrosyl ruthenium complex [Ru(NH.NHq)(tpy)NO](3+) showed the detection and quantification of nitric oxide (NO) and singlet oxygen ((1)O(2)) release. Photophysical and photochemical results demonstrated that the interaction between the nitrosyl ruthenium complex and the photosensitizer can enable an electron transfer process from the photosensitizer to the nitrosyl ruthenium complex which leads to NO release. Synergistic action of both photosensitizers and the nitrosyl ruthenium complex results in the production of reactive oxygen species and reactive nitrogen species, which is a potent oxidizing agent to many biological tissues, in particular neoplastic cells.

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