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Efeito protetor do per-condicionamento isquêmico remoto nas lesões da síndrome de isquemia e reperfusão renal em ratos

2012; Brazilian College of Surgeons; Volume: 39; Issue: 6 Linguagem: Inglês

10.1590/s0100-69912012000600014

ISSN

1809-4546

Autores

Vítor Nagai Yamaki, Thiago Barbosa Gonçalves, João Vitor Baia Coelho, Ruy Victor Simões Pontes, Felipe Lobato da Silva Costa, Marcus Vinícius Henriques Brito,

Tópico(s)

Cardiac Arrest and Resuscitation

Resumo

To evaluate the protective effect of remote ischemic per-conditioning in ischemia and reperfusion-induced renal injury.Fifteen rats (Rattus norvegicus) were randomized into three groups (n = 5): Group Normality (GN), Control Ischemia and Reperfusion (GIR) and Group remote ischemic per-conditioning (GPER). With the exception of the GN group, all others underwent renal ischemia for 30 minutes. In group GPER we performed the ischemic remote per-conditioning, consisting of three cycles of ischemia and reperfusion applied every five minutes during the ischemic period, to the left hindlimb of the rats by means of a tourniquet. To quantify the lesions we measured serum levels of creatinine and urea, as well as analyzed renal histopathology.The GPER group presented with better levels of urea (83.74 ± 14.58%) and creatinine (0.72 ± 26.14%) when compared to GIR group, approaching the GN group. Histopathologically, the lower levels of medullary congestion and hydropic degeneration were found in group GPER.The remote ischemic per-conditioning had a significant protective effect on renal ischemia and reperfusion.

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