Portal de Periódicos da CAPES

Kiss your tail goodbye: The role of PARN, Nocturnin, and Angel deadenylases in mRNA biology

2012; Elsevier BV; Volume: 1829; Issue: 6-7 Linguagem: Inglês

10.1016/j.bbagrm.2012.12.004

1876-4320

Alan R. Godwin, Shihoko Kojima, Carla B. Green, Jeffrey Wilusz,

RNA modifications and cancer

PARN, Nocturnin and Angel are three of the multiple deadenylases that have been described in eukaryotic cells. While each of these enzymes appear to target poly(A) tails for shortening and influence RNA gene expression levels and quality control, the enzymes differ in terms of enzymatic mechanisms, regulation and biological impact. The goal of this review is to provide an in depth biochemical and biological perspective of the PARN, Nocturnin and Angel deadenylases. Understanding the shared and unique roles of these enzymes in cell biology will provide important insights into numerous aspects of the post-transcriptional control of gene expression. This article is part of a Special Issue entitled: RNA Decay mechanisms.