Two New Pyridine Monoterpene Alkaloids by Chemical Conversion of a Commercial Extract of Harpagophytum procumbens
1998; American Chemical Society; Volume: 62; Issue: 2 Linguagem: Inglês
10.1021/np980149c
ISSN1520-6025
AutoresBéatrice Baghdikian, Évelyne Ollivier, R. Faure, Laurent Debrauwer, Pascal Rathelot, G. Balansard,
Tópico(s)Phytochemistry and Biological Activities
ResumoThe treatment of harpagide (1), harpagoside (2), or 8-O-p-coumaroylharpagide (3), the main iridoids of Harpagophytum procumbens and Harpagophytum zeyheri, with NH3 and HCl led to aucubinine B(4), a pyridine monoterpene alkaloid (PMTA). A similar procedure applied to a commercial extract of H. procumbens yielded 4 and two new PMTAs named beatrine A (5) and beatrine B (6). The structures of these new PMTAs were established using ESIMS and 2D NMR. Their semisynthesis was analyzed in terms of reaction mechanisms.
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