Artigo Acesso aberto Revisado por pares

Monomer-on-Monomer (MoM) Mitsunobu Reaction: Facile Purification Utilizing Surface-Initiated Sequestration

2010; American Chemical Society; Volume: 13; Issue: 1 Linguagem: Inglês

10.1021/ol1022382

ISSN

1523-7060

Autores

Pradip Maity, Alan Rolfe, Thiwanka B. Samarakoon, Saqib Faisal, Ryan D. Kurtz, Toby R. Long, Alexander Schätz, Daniel L. Flynn, Robert N. Grass, Wendelin J. Stark, Oliver Reiser, Paul R. Hanson,

Tópico(s)

Microbial Natural Products and Biosynthesis

Resumo

A monomer-on-monomer (MoM) Mitsunobu reaction utilizing norbornenyl-tagged (Nb-tagged) reagents is reported, whereby purification was rapidly achieved by employing ring-opening metathesis polymerization, which was initiated by any of three methods utilizing Grubbs catalyst: (i) free catalyst in solution, (ii) surface-initiated catalyst-armed silica, or (iii) surface-initiated catalyst-armed Co/C magnetic nanoparticles.

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