Portal de Periódicos da CAPES

Cobalt‐Mediated Mizoroki–Heck‐Type Reaction of Epoxide with Styrene

2004; Wiley; Volume: 346; Issue: 13-15 Linguagem: Inglês

10.1002/adsc.200404074

1615-4169

Yousuke Ikeda, Hideki Yorimitsu, Hiroshi Shinokubo, Koichiro Oshima,

Oxidative Organic Chemistry Reactions

Abstract Treatment of a mixture of epoxide and styrene with trimethylsilylmethylmagnesium bromide in the presence of a cobalt‐phosphine complex afforded homocinnamyl alcohol in good yield. The reaction should begin with ring opening of the epoxide by the action of magnesium bromide which leads to the formation of a magnesium 2‐bromoethoxide derivative and not with a direct single electron transfer from a cobalt complex to the epoxide.