Polarizability of G4-DNA Observed by Electrostatic Force Microscopy Measurements
2007; American Chemical Society; Volume: 7; Issue: 4 Linguagem: Inglês
10.1021/nl070013b
ISSN1530-6992
AutoresHezy Cohen, Tomer Sapir, Natalia Borovok, Tatiana Molotsky, Rosa Di Felice, Alexander Kotlyar, Danny Porath,
Tópico(s)DNA and Nucleic Acid Chemistry
ResumoG4-DNA, a quadruple helical motif of stacked guanine tetrads, is stiffer and more resistant to surface forces than double-stranded DNA (dsDNA), yet it enables self-assembly. Therefore, it is more likely to enable charge transport upon deposition on hard supports. We report clear evidence of polarizability of long G4-DNA molecules measured by electrostatic force microscopy, while coadsorbed dsDNA molecules on mica are electrically silent. This is another sign that G4-DNA is potentially better than dsDNA as a conducting molecular wire.
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