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Brown alga Ecklonia cava attenuates type 1 diabetes by activating AMPK and Akt signaling pathways

2009; Elsevier BV; Volume: 48; Issue: 2 Linguagem: Inglês

10.1016/j.fct.2009.11.004

1873-6351

Changkeun Kang, Yeung Bae Jin, Hyunkyoung Lee, Mijin Cha, Eun-tae Sohn, Jong-Hyun Moon, Cholwoo Park, Soohee Chun, Eunsun Jung, Jeong-Sook Hong, Soon Bok Kim, Jong-Shu Kim, Euikyung Kim,

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The antidiabetic therapeutic effect of Ecklonia cava, a brown alga, was investigated using streptozotocin-induced type 1 diabetes mellitus rats and C2C12 myoblasts. The methanol extract of E. cava (ECM), having a strong radical scavenging activity, significantly reduced plasma glucose level and increased insulin concentration in type 1 diabetes mellitus rats. Moreover, the elevation of plasma ALT in diabetic rats was dramatically restored near to normal range by the treatment of ECM, whereas AST level was not meaningfully altered in any group throughout the experiment. The characteristic indications of diabetes, such as polyphagia and polydipsia, were greatly improved by ECM treatment as well. The mechanism of action of ECM appears to be, at least partially, mediated by the activation of both AMP-activated protein kinase/ACC and PI-3 kinase/Akt signal pathways. Taken together, the present results suggest that E. cava has both in vivo and in vitro antidiabetic effects.