An update on the medical management of breast cancer
2014; Volume: 348; Issue: jun09 1 Linguagem: Inglês
10.1136/bmj.g3608
ISSN1756-1833
AutoresBelinda Yeo, Nicholas C. Turner, A. Jones,
Tópico(s)Global Cancer Incidence and Screening
Resumo#### Summary points Breast cancer remained the most common cancer in women in 2013 and its incidence continues to rise.1 Nonetheless, mortality is falling, partly as a result of earlier diagnosis through mammographic screening,2 improved surgical techniques and attention to margins, improved delivery of radiotherapy, and better adjuvant medical therapies (fig 1⇓). Despite these improvements, breast cancer remains the second most common cause of death from cancer in women. Fig 1 Incidence of breast cancer in women and mortality rates in the United Kingdom over the past 30 years. Data from Cancer Research UK1 This review focuses on the medical treatment of breast cancer in the adjuvant and metastatic settings, with particular attention to recent advances and changes in practice since our last review in 2008.3 4 We discuss how targeted therapies can be used to individualise and tailor the management of breast cancer according to tumour biology and molecular subtype. #### Sources and selection criteria We used PubMed to identify recent published updates on the medical management of breast cancer. We also referenced presentations from international conferences and consulted with other experts in the breast cancer field. ### Diagnosis Guidelines on the diagnosis of early breast cancer have changed little since our last review. Population based mammography screening for asymptomatic women is currently …
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