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Prevalence of Herpes B Virus Antibody in Nonhuman Primates reared at the National University of Japan.

1998; Volume: 47; Issue: 3 Linguagem: Inglês

10.1538/expanim.47.199

1884-4170

Hiroshi Sato, Jiro Arikawa, Masato Furuya, Junzoh Kitoh, Kazuaki Mannen, Yoshitake Nishimune, Kazutaka Ohsawa, Tadao Serikawa, Toshiyuki Shibahara, Yoji WATANABE, Ken‐ichi Yagami, Hiroshi Yamamoto, Yasuhiro Yoshikawa,

Immunotherapy and Immune Responses

A serological investigation by means of an enzyme immuno assay test for herpes B virus (cercopithecine herpesvirus 1) was performed on 961 sera of healthy nonhuman primates reared in laboratory animal facilities which belong to the Association of Laboratory Animal Facilities of the National University of Japan. An antibody prevalence of 40% (384/961) was demonstrated. The antibody titer was shown to be higher among macaques (60% of cynomolgus monkeys, 53% of rhesus monkeys, and 34% of Japanese monkeys) than among non-macaque species (21%). These data indicate that nonhuman primates reared in animal facilities may present an occupational health problem and a potential zoonotic biohazard as demonstrated in limited cases in the United States.