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Variations of Susceptibility to Alloxan Induced Diabetes in the Rabbit

1987; Thieme Medical Publishers (Germany); Volume: 19; Issue: 11 Linguagem: Inglês

10.1055/s-2007-1011876

1439-4286

Ze Hua Zhao, Bruno Watschinger, C. Hendricks Brown, Monica M. Beyer, Eva Friedman,

Adipose Tissue and Metabolism

The variations of susceptibility to alloxan induced Diabetes in a total of seventeen rabbits was described. Our study was designed to explore dosage schedules which might improve rabbit responsiveness to and survival after alloxan treatment. A wide range of response to intravenously administered alloxan was observed. Permanent diabetes (blood glucose 350 mg/dl) was found in three rabbits after a single injection (60 mg/kg in one, 100 mg/kg in two). This effect has persisted for eight months. By contrast, two other rabbits injected with a single dose of alloxan (60 mg/kg) developed only transient hyperglycemia. Similarly, four other rabbits either did not respond or had an incomplete response after receiving a total dose of 120 mg/kg. These data suggest that there is extreme variability in individual rabbits susceptibility to the diabetogenic affects of alloxan.