Hypoxia of the Renal Medulla — Its Implications for Disease
1995; Massachusetts Medical Society; Volume: 332; Issue: 10 Linguagem: Inglês
10.1056/nejm199503093321006
ISSN1533-4406
Autores Tópico(s)Thermal Regulation in Medicine
ResumoIn land mammals, a major task of the kidney is to reabsorb water to allow survival in a dry environment. Water conservation is enhanced by the renal medulla, which concentrates the urine to a level up to four times the osmolality of plasma. To produce this unique gradient of osmolality, the medulla has a countercurrent system of vessels and tubules that dictates active reabsorption of sodium in a milieu poor in oxygen (Figure 1).1 In this review, we describe how hypoxia of the medulla may relate to susceptibility to acute and chronic renal injury.The Renal Medullary Concentrating Mechanism as . . .
Referência(s)