Haplogroup analysis of the risk associated with APOE promoter polymorphisms (−219T/G, −491A/T and −427T/C) in Colombian Alzheimer's disease patients
2003; Elsevier BV; Volume: 349; Issue: 3 Linguagem: Inglês
10.1016/s0304-3940(03)00816-4
ISSN1872-7972
AutoresGlenda Parra‐Bonilla, Gonzalo Arboleda, Juan J. Yunis, Eugenia Solano, Rodrigo Pardo, Gabriel Arango, Daniel Hedmont, Humberto Arboleda,
Tópico(s)Lipoproteins and Cardiovascular Health
ResumoResults analyzing the association between polymorphisms in the promoter region of the apolipoprotein E (APOE) gene and Alzheimer's disease (AD) are contradictory. We studied the association of three polymorphisms in the APOE promoter (−219T/G, −491A/T and −427T/C) with AD in a sample of the Colombian population. The polymorphism −491A/T confers increased risk for AD associated with AA genotype independent of APOEe4 allele (odds ratio (OR): 2.64) and more pronounced in men (OR: 6.07). Genotypes TT and TG of −219T/G showed a significant association with AD, but this was lost in an adjusted model. We did not find any association with −427T/C polymorphism. Using a haplogroup analysis of the promoter polymorphisms, we further confirmed their independent contribution as genetic risk factors for AD.
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