Cytotoxicity, antioxidant and anti-inflammatory activities of Curcumins I–III from Curcuma longa
2000; Elsevier BV; Volume: 7; Issue: 4 Linguagem: Inglês
10.1016/s0944-7113(00)80048-3
ISSN1618-095X
AutoresRussel S. Ramsewak, David L. DeWitt, Muraleedharan G. Nair,
Tópico(s)Natural product bioactivities and synthesis
ResumoCurcumin I, curcumin II (monodemethoxycurcumin) and curcumin III (bisdemethoxycurcumin) from Curcuma longa were assayed for their cytotoxicity, antioxidant and anti-inflammatory activities. These compounds showed activity against leukemia, colon, CNS, melanoma, renal, and breast cancer cell lines. The inhibition of liposome peroxidation by curcumins I–III at 100 μg/ml were 58, 40 and 22 %, respectively. The inhibition of COX-I and COX-II enzymes by the curcumins was observed. Curcumins I–III were active against COX-I enzyme at 125 μg/ml and showed 32, 38.5 and 39.2 % inhibition of the enzyme, respectively. Curcumins I-III also showed good inhibition of the COX-II enzyme at 125 μg/ml with 89.7, 82.5 and 58.9 % inhibition of the enzyme, respectively.
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