LOW RENIN-ANGIOTENSIN SYSTEM ACTIVITY GENE POLYMORPHISM AND DYSPLASIA ASSOCIATED WITH POSTERIOR URETHRAL VALVES
2005; Lippincott Williams & Wilkins; Volume: 174; Issue: 2 Linguagem: Inglês
10.1097/01.ju.0000164739.13408.e2
ISSN1527-3792
AutoresLicia Peruzzi, Federica Lombardo, Alessandro Amore, Emilio Merlini, Gabriella Restagno, L Silvestro, Teresa Papalia, Rosanna Coppo,
Tópico(s)Renal and related cancers
ResumoNo AccessJournal of UrologyPediatric Urology1 Aug 2005LOW RENIN-ANGIOTENSIN SYSTEM ACTIVITY GENE POLYMORPHISM AND DYSPLASIA ASSOCIATED WITH POSTERIOR URETHRAL VALVES LICIA PERUZZI, FEDERICA LOMBARDO, ALESSANDRO AMORE, EMILIO MERLINI, GABRIELLA RESTAGNO, LEANDRA SILVESTRO, TERESA PAPALIA, and ROSANNA COPPO LICIA PERUZZILICIA PERUZZI , FEDERICA LOMBARDOFEDERICA LOMBARDO , ALESSANDRO AMOREALESSANDRO AMORE , EMILIO MERLINIEMILIO MERLINI , GABRIELLA RESTAGNOGABRIELLA RESTAGNO , LEANDRA SILVESTROLEANDRA SILVESTRO , TERESA PAPALIATERESA PAPALIA , and ROSANNA COPPOROSANNA COPPO View All Author Informationhttps://doi.org/10.1097/01.ju.0000164739.13408.e2AboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract Purpose: Obstructive uropathies, including posterior urethral valves (PUVs) and kidney hypodysplasia, are the most frequent cause of renal failure in children. The role of renin-angiotensin system genes in renal and urinary tract development has been observed in experimental models. The aim of this study was to investigate the distribution of angiotensin converting enzyme (ACE), angiotensinogen (AGT) and angiotensin receptor type 1 (ATR1) genetic polymorphisms in children affected by chronic renal failure due to renal hypodysplasia associated with posterior urethral valves or without urethral abnormalities. Materials and Methods: The study included 50 children (21 with hypodysplasia associated with PUVs, 7 with obstructive uropathy and 22 with pure hypodysplasia) and 50 healthy subjects matched for sex and geographic origin. ACE ID, AGT TC and ATR1 AC gene polymorphisms were assayed in all patients with standard polymerase chain reaction techniques. Results: ACE II was expressed more in patients with PUVs compared to those with other dysplasias and controls (43% vs 7% and 10%, respectively, chi-square test p <0.05), while ATR1 AA was significantly less represented in patients with hypodysplasia compared to controls (38% vs 56%, chi-square test p <0.05). ACE DD and AGT genotypes were not distributed differently in patients with PUVs compared to those with other dysplasias and controls. Conclusions: To our knowledge this is the first report associating severe congenital uropathies and renal hypodysplasia with decreased renin-angiotensin system activity associated with the ACE II genotype and a possible functional imbalance among ATR1 receptors. References 1 : Chronic renal insufficiency in children: the 2001 Annual Report of the NAPRTCS. Pediatr Nephrol2003; 18: 796. Google Scholar 2 : Fetal obstructive uropathy: patterns of renal pathology. Pediatr Dev Pathol2000; 3: 223. 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Annunziata Hospital, Cosenza (TP), Italy© 2005 by American Urological Association, Inc.FiguresReferencesRelatedDetails Volume 174Issue 2August 2005Page: 713-717 Advertisement Copyright & Permissions© 2005 by American Urological Association, Inc.Keywordskidney failure, chronicrenin-angiotensin systemurogenital abnormalitiespolymorphism, geneticurethraMetricsAuthor Information LICIA PERUZZI More articles by this author FEDERICA LOMBARDO More articles by this author ALESSANDRO AMORE More articles by this author EMILIO MERLINI More articles by this author GABRIELLA RESTAGNO More articles by this author LEANDRA SILVESTRO More articles by this author TERESA PAPALIA More articles by this author ROSANNA COPPO More articles by this author Expand All Advertisement PDF downloadLoading ...
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