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Aneuploidy in sperm and exposure to fungicides and lifestyle factors

1999; Wiley; Volume: 34; Issue: 1 Linguagem: Inglês

10.1002/(sici)1098-2280(1999)34

1098-2280

Kati H�rk�nen, Tommi Viitanen, S. B. Larsen, Jens ­Peter Bonde, Jaana L�hdetie,

Prenatal Screening and Diagnostics

Environmental and Molecular MutagenesisVolume 34, Issue 1 p. 39-46 Research Article Aneuploidy in sperm and exposure to fungicides and lifestyle factors Kati Härkönen, Corresponding Author Kati Härkönen [email protected] Department of Medical Genetics, University of Turku, Turku, Finland Turku Graduate School of Biomedical Sciences, Turku, FinlandDepartment of Medical Genetics, University of Turku, Turku, FinlandSearch for more papers by this authorTommi Viitanen, Tommi Viitanen Department of Statistics, University of Turku, Turku, FinlandSearch for more papers by this authorSolveig Brixen Larsen, Solveig Brixen Larsen Department of Occupational Medicine, Aarhus University Hospital, Aarhus, DenmarkSearch for more papers by this authorJens Peter Bonde, Jens Peter Bonde Department of Occupational Medicine, Aarhus University Hospital, Aarhus, DenmarkSearch for more papers by this authorJaana Lähdetie, Jaana Lähdetie Department of Medical Genetics, University of Turku, Turku, Finland Department of Child Neurology, Turku University Central Hospital, Turku, FinlandSearch for more papers by this author Kati Härkönen, Corresponding Author Kati Härkönen [email protected] Department of Medical Genetics, University of Turku, Turku, Finland Turku Graduate School of Biomedical Sciences, Turku, FinlandDepartment of Medical Genetics, University of Turku, Turku, FinlandSearch for more papers by this authorTommi Viitanen, Tommi Viitanen Department of Statistics, University of Turku, Turku, FinlandSearch for more papers by this authorSolveig Brixen Larsen, Solveig Brixen Larsen Department of Occupational Medicine, Aarhus University Hospital, Aarhus, DenmarkSearch for more papers by this authorJens Peter Bonde, Jens Peter Bonde Department of Occupational Medicine, Aarhus University Hospital, Aarhus, DenmarkSearch for more papers by this authorJaana Lähdetie, Jaana Lähdetie Department of Medical Genetics, University of Turku, Turku, Finland Department of Child Neurology, Turku University Central Hospital, Turku, FinlandSearch for more papers by this author First published: 25 August 1999 https://doi.org/10.1002/(SICI)1098-2280(1999)34:1 3.0.CO;2-FCitations: 63AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinkedInRedditWechat Abstract Fungicides include chemicals that are known aneugens. The purpose of the present study was to investigate whether occupational exposure to these and other agricultural pesticides induces aneuploidy in human sperm. The contribution of lifestyle factors (smoking and alcohol consumption) to the frequency of aneuploid sperm was evaluated as well. The effects of age and sperm concentration were analyzed as confounders. Spermatozoa from 30 healthy farmers were studied before and after exposure to fungicides, using fluorescence in situ hybridization (FISH). Ten thousand spermatozoa were scored per semen sample to determine the disomy and diploidy frequencies for chromosomes 1 and 7. Exposure to fungicides was not associated with sperm aneuploidy. Smoking was significantly associated with sperm carrying an extra chromosome 1 and with diploid sperm as well as with the aggregate frequency of aneuploid sperm. Alcohol consumption, sperm concentration, and age showed inconsistent results before and after the season of exposure to fungicides. For low-level exposures, such as occupational exposures, the sensitivity of the sperm-FISH method may not be sufficient. The present study supports earlier ones showing that smoking can increase aneuploidy in human sperm. Environ. Mol. Mutagen. 34:39–46, 1999 © 1999 Wiley-Liss, Inc. Citing Literature Volume34, Issue11999Pages 39-46 RelatedInformation