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Molecular interaction in monolayers II—The action of haemolytic and agglutinating agents on lipo-protein monolayers

1937; Royal Society; Volume: 122; Issue: 826 Linguagem: Inglês

10.1098/rspb.1937.0009

2053-9193

J. H. Schulman, Eric Keightley Rideal,

Bacteriophages and microbial interactions

In Schulman and Rideal (1937) several examples were given of the sensitivity in the extent of association in molecular interaction between molecules containing both polar and non-polar groups to slight alterations in the reactivities of either of these portions. In this paper an account is given of the interaction between organic molecules and protein monolayers and of the properties of these synthetic systems. It will be shown that they suggest possible mechanisms for the biological processes of lysis, agglutination, and sensitization. Two types of complex formation between molecules injected into the substrate and the molecules forming the monolayer have been established, those in which mutual association takes place by means of their polar groups alone, and those, the penetrating molecules, in which association is the result of the mutual interaction both of the polar and non-polar portions of the molecules.