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Phenolic and Antibacterial Constituents of Vahlia capensis

1997; Thieme Medical Publishers (Germany); Volume: 63; Issue: 03 Linguagem: Inglês

10.1055/s-2006-957671

1439-0221

Runner R.T. Majinda, Modisa S. Motswaledi, Roger D. Waigh, Peter G. Waterman,

Natural Compound Pharmacology Studies

The n-butanol fraction of Vahlia capensis yielded kaempferol, quercetin, afzelin, astragalin, quercitrin, iso-quercitrin, rutin, gallic acid, chiro-inositol, dulcitol, and a novel biflavonoid, VC-15B (vahlia biflavone). The compounds were identified using ID and 2D NMR techniques and FABMS. Vahlia biflavone and gallic acid were isolated, using bioassay-guided procedure and identified as the antibacterial components. Both compounds showed activity against Gram positive Staphylococcus aureus and Bacillus subtilis. Vahlia biflavone gave MIC values of 15.3 µg/ml and 30.6 µg/ml against S. aureus and B. subtilis, respectively while gallic acid gave a value of 71.3 µg/ml for both organisms.