Tryptoline Formation by a Preparation from Brain with 5-Methyltetrahydrofolic Acid and Tryptamine
1975; American Association for the Advancement of Science; Volume: 187; Issue: 4179 Linguagem: Inglês
10.1126/science.234627
ISSN1095-9203
AutoresRichard Jed Wyatt, Elizabeth Erdelyi, Jefferson R. DoAmaral, Glen R. Elliott, J Renson, Jack D. Barchas,
Tópico(s)Synthesis and Biological Evaluation
ResumoAn enzymatic preparation from human brain converts tryptamine to tryptoline (9H-1,2,3,4-tetrahydropyrido[3,4-b]indole) in the presence of 5-methyltetrahydrofolic acid. Similarly, N-methyltryptamine and 5-hydroxytryptamine yield 1-methyltryptoline and 5-hydroxytryptoline, respectively. Neither in vitro nor in vivo formation of these compounds by human tissues has been described.
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