Role of Interleukin‐2 in the Age‐Related Impairment of Immune Function
1985; Wiley; Volume: 33; Issue: 11 Linguagem: Inglês
10.1111/j.1532-5415.1985.tb04191.x
ISSN1532-5415
Autores Tópico(s)IL-33, ST2, and ILC Pathways
ResumoJournal of the American Geriatrics SocietyVolume 33, Issue 11 p. 781-787 Role of Interleukin-2 in the Age-Related Impairment of Immune Function Dr. Marilyn L. Thoman PhD, Corresponding Author Dr. Marilyn L. Thoman PhD Department of Immunology, Scripps Clinic and Research Foundation, La Jolla, CaliforniaDepartment of Immunology IMM9, Scripps Clinic and Research Foundation, 10666 North Torrey Pines Road, La Jolla, CA 92037Search for more papers by this author Dr. Marilyn L. Thoman PhD, Corresponding Author Dr. Marilyn L. Thoman PhD Department of Immunology, Scripps Clinic and Research Foundation, La Jolla, CaliforniaDepartment of Immunology IMM9, Scripps Clinic and Research Foundation, 10666 North Torrey Pines Road, La Jolla, CA 92037Search for more papers by this author First published: November 1985 https://doi.org/10.1111/j.1532-5415.1985.tb04191.xCitations: 20 This is publication 3804-IMM from the Department of Immunology, Scripps Clinic and Research Foundation, La Jolla, CA. Supported in part by US Public Health Service grants AG01743, AG00783, and a grant from the American Federation for Aging Research, Inc. Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL References 1 Makinodan T, Kay M: Age influence on the immune system. Adv Immunol 29: 287, 1980. 2 Kay M, Makinodan T: Relationship between aging and the immune system. Prog Allergy 29: 134, 1981. 3 Gardner I, Remington J: Aging and the immune response. I. Antibody formation and chronic infection in toxoplasma gondii infected mice. J Immunol 120: 939, 1978. 4 Gardner I, Remington J: Aging and the immune response. II. Lymphocyte responsiveness and macrophage activation in toxoplasma gondii infected mice. J Immunol 120: 944, 1978. 5 Patel P: Aging and antimicrobial immunity, impaired production of mediator T cells as a basis for the decreased resistance of senescent mice to Listeriosis. J Exp Med 154: 821, 1981. 6 Yoshikawa T: Geriatric infectious disease: An emerging problem. J Am Geriatr Soc 31: 34, 1983. 7 Inkeles B, Innes J, Kuntz M, et al: Immunological studies of aging III cytokinetic basis for the impaired response of lymphocytes from aged humans to plant lectins. J Exp Med 145: 1176, 1977. 8 Hefton J, Darlington G, Casazza B, et al: Immunologic studies of aging. V. Impaired proliferation of PHA responsive human lymphocytes in culture. J Immunol 125: 1007, 1980. 9 Tice R, Schneider E, Kram D, et al: Cytokinetic analysis of the impaired proliferative response of peripheral lymphocytes from aged humans to phytohemagglutinin, J Exp Med 1: 1029, 1979. 10 Watson J, Mochizuki D: Interleukin 2: A class of T cell growth factors. Immunol Rev 51: 257, 1980. 11 Schrader J, Clark-Lewis I, Barlett P: T-cell hybridoma-derived lymphokines: Biology and biochemistry of factors regulating hemopoietic and lymphoid cells. Lymphokines 5: 291, 1982. 12 Kehrl J, Muraguchi A, Butler J, et al: Human B cell activation, proliferation and differentiation. Immunol Rev 78: 75, 1984. 13 Howard M, Paul W: Regulation of B-cell growth and differentiation by soluble factors. Ann Rev Immunol 1: 307, 1984. 14 Watson J, Frank M, Mochizuki D, et al: The biochemistry and biology of Interleukin 2. Lymphokines 6: 95, 1982. 15 Smith K, Baker P, Gillis S, et al: Functional molecular characteristics of T-cell growth factor. Mol Immunol 17: 579, 1980. 16 Wagner H, Hardt C, Heeg K, et al: T-T cell interactions during cytotoxic T lymphocyte (CTL) responses: T cell-derived helper factor (Interleukin 2) as a probe to analyze CTL responsiveness and thymic maturation of CTL progenitors. Immunol Rev 51: 215, 1980. 17 Ralph P, Jeong G, Welte K, et al: Stimulation of immunoglobulin secretion in human B lymphocytes as a direct effect of high concentrations of IL-2. J Immunol 133: 2442, 1984. 18 Maraguchi A, Kehrl J, Longo D, et al: Interleukin 2 receptors on human B cells. Implications for the role of interleukin 2 in human B cell function. J Exp Med 161: 181, 1985. 19 Dinarello C: Interleukin-1. Rev Infect Dis 6: 51, 1984. 20 Cantrell D, Smith K: The interleukin-2 T-cell system: A new cell growth model. Science 224: 1312, 1984. 21 Cantrell D, Smith K: Transient expression of interleukin 2 receptors. Consequences for T cell growth. J Exp Med 158: 1895, 1983. 22 Robb R, Munck A, Smith K: T cell growth factor receptors. Quantitation, specificity, and biological relevance. J Exp Med 154: 1455, 1981. 23 Miyasaka N, Nakamura T, Russell I, et al: Interleukin 2 deficiencies in rheumatoid arthritis and systemic lupus erythematosus. Immunol Immunopathol 31: 109, 1984. 24 Smith J, Knowlton, R, Koons L: Immunologic studies in chronic lymphocytic leukemia: defective stimulation of T-cell proliferation in autologous mixed lymphocyte culture. J Natl Cancer Inst 58: 579, 1977. 25 Ruscetti F, Gallo R: Human T lymphocyte growth factor: regulation of growth and function of T lymphocytes. Blood 57: 379, 1981. 26 Mochizuki D, Watson J, Gillis S: Biochemical separation of interleukin 2. J Immunol Methods 39: 185, 1980. 27 Goodwin J, Messner R: Sensitivity of lymphocytes to prostaglandin E2 increases in subjects over age 70. J Clin Invest 64: 434, 1979. 28 Chouaib S, Fradelizi D: The mechanism of inhibition of human IL-2 production. J Immunol 129: 2463, 1982. 29 Tilden A, Balch C: A comparison of PGE2 effects on human suppressor cell function and on Interleukin 2 function, J Immunol 129: 2469, 1982. 30 Rappaport R, Dodge G: Prostaglandin E inhibits the production of human interleukin 2. J Exp Med 155: 943, 1982. 31 Donohue J, Rosenberg S: The fate of interleukin-2 after in vivo administration. J Immunol 130: 2203, 1983. 32 Rosenberg S, Grimm E, McGrogan H, et al: Biological activity of recombinant human interleukin-2 produced in Escherichia coli. Science 223: 1412, 1984. 33 Wang A, Lu S, Mark D: Site specific mutagenesis of the human Interleukin-2 gene: Structure-function analysis of the cysteine residues. Science 224: 1431, 1984. 34 Price G, Makinodan T: Lymphokines and aging: Interleukin 2 production and activity in aged animals. J Immunol 108: 403, 1972. 35 Thoman M, Weigle W: Lymphokines and aging: Interleukin 2 production and activity in aged animals. J Immunol 127: 2102, 1981. 36 Thoman H, Weigle W: Cell-mediated Immunity in aged mice: An underlying lesion in IL-2 synthesis. J Immunol 128: 2358, 1982. 37 Thoman M, Weigle W: Reconstitution of in vivo cell-mediated lympholysis responses in aged mice with interleukin 2. J Immunol 134: 949, 1985. 38 Bruley-Rosset M, Vergnon I: Interleukin-1 synthesis and activity in aged mice. Mech Ageing Dev 24: 247, 1984. 39 Grinblat J, Schauenstein K, Saltz E, et al: Regulatory effects of thymus humoral factor on T cell growth factor in aging mice. Mech Ageing Dev 22: 209, 1983. 40 Chang M, Makinodan T, Peterson W, et al: Role of T cells and adherent cells in age-related decline in murine Interleukin 2 production. J Immunol 129: 2426, 1982. 41 Miller R, Stutman O: Limiting dilution analysis of IL-2 production: Studies of age, genotype, and regulatory Interactions. Lymphokine Res 1: 79, 1982. 42 Harrison D, Doubleday J: Normal function of immunologic stem cells from aged mice. J Immunol 114: 1314, 1977. 43 Harrison D, Astle C, Doubleday J: Stem cell lines from old immunodeficient donors give normal responses in young recipients. J Immunol 118: 1223, 1977. 44 Astle C, Harrison D: Effects of marrow donor and recipient age on immune responses. J Immunol 132: 673, 1984. 45 Goldstein A, Low T, Thuman G, et al: Current status of thymosin and other hormones of the thymus gland. Recent Prog Horm Res 37: 369, 1981. 46 Frasca D, Garavini M, Doria G: Recovery of T-cell functions in aged mice injected with synthetic thymosin-α1. Cell Immunol 72: 384, 1982. 47 Weksler M, Innes J, Goldstein G: Immunological studies of aging. IV. The contribution of thymic involution to the immune deficiencies of aging mice and reversal with thymopoietin 32–36. J Exp Med 148: 996, 1978. 48 D'Agostaro G, Frasca D, Gararini M, et al: Immunorestoration of old mice by injection of thymus extract: Enhancement of T cell-T cell cooperation in the in vitro antibody response. Cell Immunol 53: 207, 1980. 49 Ghanta V, Noble P, Brown M, et al: Alloreactivity. I. Effects of age and thymic hormone treatment on cell-mediated immunity in C57BL/6NNia mice. Mech Ageing Dev 22: 309, 1983. 50 Ershler W, Moore A, Hacker M, et al: Specific antibody synthesis in vitro. II. Age-associated thymosin enhancement of antitetanus antibody synthesis. Immunopharmacology 8: 69, 1984. 51 Zatz M, Oliver J, Samuels C, et al: Thymosin increases production of T-cell growth factor by normal human peripheral blood lymphocytes. Proc Natl Acad Sci USA 81: 2882, 1984. 52 Green D, Gershon R, Eardley D: Function and deletion of different Ly-1 T cell-inducer subset activities of Ly-2 suppressor T lymphocytes. Proc Natl Acad Sci USA 78: 3819, 1981. 53 Thoman M, Weigle W: Deficiency in suppressor T cell activity in aged animals. Reconstitution of this activity by interleukin 2. J Exp Med 157: 2184, 1983. 54 Rosenberg J, Gilman S, Feldman J: Effects of aging on cell cooperation and lymphocyte responsiveness to cytokines. J Immunol 130: 1754, 1983. 55 de Weck A, Kristensen F, Joncourt F, et al: Lymphocyte proliferation, lymphokine production, and lymphocyte receptors in ageing and various clinical conditions. Springer Semin Immunopathol 7: 273, 1984. 56 Jerne N, Nordin A: Plaque formation in agar by single antibody producing cells. Science 140: 405, 1963. Citing Literature Volume33, Issue11November 1985Pages 781-787 ReferencesRelatedInformation
Referência(s)