Hipokalemia, hipovolemia y repercusión electrocardiográfica secundarias a ingesta prolongada de furosemida: Caso clínico
2007; Q16635223; Volume: 135; Issue: 11 Linguagem: Inglês
10.4067/s0034-98872007001100013
ISSN0717-6163
AutoresCésar Aravena, I. Salas, Rodrigo Tagle, Aquiles Jara, Rodrigo Miranda, Paul McNab, José Ángel Rodríguez, Gloría Valdés, Andrés Valdivieso,
Tópico(s)Ion channel regulation and function
ResumoHypokalemia, hypovolemia and electrocardiographic changes due to furosemide abuse.Report of one case Hypokalemia (serum K + <3.5 mEq/l) is a potentially serious adverse effect of diuretic ingestion.We report a 27 year-old woman admitted with muscle weakness, a serum potassium of 2.0 mEq/1, metabolic alkalosis and EKG abnormalities simulating cardiac ischemia, that reverted with potassium chloride administration.She admitted high dose furosemide self-medication for edema.Glomerular filtration rate, tubular sodium reabsortion, potassium secretion, the renin-aldosterone system, total body water distribution and capillary permeability, were studied sequentially until 90 days after her admission.There was hyperactivity of the renin-aldosterone axis, reduction in extracellular and intracellular volumes, normal capillary permeability and high sodium tubular reabsorption, probably explained by a "rebound" salt retention associated with her decreased extracellular volume (Rev Méd Chile 2007; 135: 1456-62).
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