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Dexamethasone partially reduces and 2% saline-treatment abolished electroacupuncture analgesia: These findings implicate pituitary endorphins

1979; Elsevier BV; Volume: 24; Issue: 16 Linguagem: Inglês

10.1016/0024-3205(79)90031-6

1879-0631

Richard Cheng, Bruce Pomeranz, George Yü,

Stress Responses and Cortisol

Dexamethasone, a cortisol analogue which inhibits ACTH and endorphin release in a negative feedback system, partially reduces electroacupuncture analgesia (EAA) in mice. In addition, mice forced to drink 2% saline for 3 days (this reduces pituitary endorphin levels) had a complete loss of EAA. These two experiments support our previous finding that hypophysectomy abolishes EAA. Altogether, these results implicate pituitary endorphins in EAA.