The octamers d(CGCGCGCG) and d(CGCATGCG) both crystallize as Z‐DNA in the same hexagonal lattice
1985; Wiley; Volume: 24; Issue: 1 Linguagem: Inglês
10.1002/bip.360240118
ISSN1097-0282
AutoresSatoshi Fujii, Andrew H.‐J. Wang, Gary J. Quigley, H. P. Westerink, Gijs van der Marel, Jacques H. van Boom, Alexander Rich,
Tópico(s)DNA and Biological Computing
ResumoAbstract Both (dC‐dG) 4 and d(CGCATGCG) crystallize in hexagonal lattices and their three‐dimensional structure has been solved by x‐ray diffraction analysis. Both molecules are found to form Z‐DNA, although the fine details of the structure cannot be visualized due to the statistical disordering of the molecules along the c ‐axis, which is brought about by the symmetry constraints of the space group. This represents the first time in which the unmodified dinucleotide sequences CpAp and TpGp have been found to form Z‐DNA in a crystalline lattice.
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