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Treatment of relapsing acute lymphoblastic leukemia in childhood. III. Experiences with 54 first bone marrow, nine isolated testicular, and eight isolated central nervous system relapses observed 1985‐1989

1994; Alan R. Liss, Inc.; Volume: 22; Issue: 6 Linguagem: Inglês

10.1002/mpo.2950220602

1096-911X

Nicolas von der Weid, Bendicht Wagner, Regula Angst, Beat Arnet, Christoph Baumgartner, Daniel von der Beck, Arnold Bleher, Ueli Caflisch, B Delaleu, A Feldges, Eva Frey, Ingeborg Glanzmann, Andreas Hirt, Paul Imbach, Silke Kratel, Henri Küchler, Kurt Leibundgut, Andreas Meister, Anne‐Marie Morin, Luisa Nobile, Hans‐Juerg Plüss, A Lüthy, E Signer, Erich Stettler, Marinette Wyss, Hans‐Peter Wagner,

Hematopoietic Stem Cell Transplantation

Of 54 children with acute lymphoblastic leukemia (ALL) and first hematological recurrence observed between 1985 and 1989, 31 relapsed while still on treatment and 23 after cessation of therapy. Of the former, only one survived. Of the latter, 11 children survived after a minimum follow-up of 25 months. During the same period, a first isolated testicular relapse was observed in nine boys, of whom six survived, and an isolated CNS relapse in eight patients, of whom three survived. As a rule, survivors of a bone marrow or testicular relapse were doing well while those surviving a CNS relapse had considerable neuropsychological sequelae. These results, compared with those of two preceding studies, suggest that with intensification of front-line treatments, it becomes more difficult to rescue children who relapse, particularly those with a bone marrow relapse while on therapy.