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Artigo Produção Nacional Revisado por pares
BIBTEX RIS

Beneficial effects of Anadenanthera colubrina (Vell.) Brenan extract on the inflammatory and nociceptive responses in rodent models

2013; Elsevier BV; Volume: 148; Issue: 1 Linguagem: Inglês

10.1016/j.jep.2013.04.012

ISSN

1872-7573

Autores

Jandson S. Santos, Renata Ribeiro Marinho, Eduardo Ekundi-Valentim, A. David Rodrigues, Marcelo H. Yamamoto, Simone A. Teixeira, Marcelo N. Muscará, Soraia K.P. Costa, Sara M. Thomazzi,

Tópico(s)

Sesquiterpenes and Asteraceae Studies

Resumo

Anadenanthera colubrina (Vell.) Brenan, popularly known as "angico", is a plant that has been widely used in folk medicine due to its anti-inflammatory property. To evaluate the pharmacological activities of this plant, studies were performed on its antinociceptive and anti-inflammatory properties. The AE of Anadenanthera colubrina, made from the bark, was used in rodents via oral route (p.o.), at 100, 200, and 400 mg/kg in classical models of nociception (acetic acid-induced writhing and hot-plate test) and inflammation evoked by carrageenan (e.g., paw edema, peritonitis, and synovitis). The acetic acid-induced abdominal writhes in mice were significantly reduced (P<0.001) by oral treatment with the extract (100, 200, and 400 mg/kg), but the extract did not significantly increase the latency in the nociceptive hot-plate test. Anadenanthera colubrina aqueous extract reduced significantly the edema and, besides, diminished the mieloperoxidase activity (200 and 400 mg/kg, P<0.01). The carrageenan-induced peritonitis was significantly reduced (P<0.05) by the aqueous extract at 100, 200, and 400 mg/kg. The aqueous extract (200 mg/kg) reduces the synovial leukocyte infiltration on carrageenan-induced synovitis in rats (P<0.01), but failed to significantly affect joint swelling and impaired mobility. We show for the first time that the anti-inflammatory and peripheral antinociceptive activities of Anadenanthera colubrina are consistent, at least in part, with the use of this plant in popular medicine practices.

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