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Specific Alkylation of Guanine Opposite to a Single Nucleotide Bulge: A Chemical Probe for the Bulged Structure of DNA

1999; Wiley; Volume: 38; Issue: 22 Linguagem: Inglês

10.1002/(sici)1521-3773(19991115)38

1521-3773

Kazuhiko Nakatani, Akimitsu Okamoto, Isao Saito,

RNA Interference and Gene Delivery

Remarkable enhancement of guanine alkylation just opposite a bulged site by 13R-1 compared with those in normal duplex DNA is ascribable to the formation of a unique intercalated complex that is attainable only at the bulged sites (see picture). This observation suggests that 13R-1 can be used as a chemical probe for the bulged structure of DNA.