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In vitro effect of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) on muscarinic cholinergic receptors in mouse striatum

1989; Elsevier BV; Volume: 94; Issue: 2 Linguagem: Inglês

10.1016/0742-8413(89)90123-0

1878-1969

Yoorock Suh, M. Cho, J.I. Woo, C.W. Park,

Nicotinic Acetylcholine Receptors Study

1. MPTP significantly lowered Kd of the binding of [3H]QNB to muscarine receptor without affecting Bmax values compared with those of control. Hill coefficients (nH) of control and MPTP (250 μM) added group were 1.15 ± 0.127 and 0.56 ±0.202, respectively. 2. Prior addition of pargyline to MPTP did not prevent the decrease of [3H]QNB binding. The patterns of displacement of [3H]QNB by MPTP and MPP+ were similar to those by some muscarinic agonists, such as acetylcholine, carbamyl choline and methacholine. 3. These results suggest that MPTP might be muscarinic agonist and might play a role to produce Parkinsonism through directly affecting the muscarinic cholinergic receptors in vivo.