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Microbial reduction of ethyl 2-oxo-4-phenylbutyrate. Searching for R-enantioselectivity. New access to the enalapril like ACE inhibitors

2006; Elsevier BV; Volume: 17; Issue: 8 Linguagem: Inglês

10.1016/j.tetasy.2006.04.008

1362-511X

Paulo Sérgio Bergo de Lacerda, Joyce Benzaquem Ribeiro, Selma Gomes Ferreira Leite, Maria Antonieta Ferrara, Ricardo B. Coelho, Elba P. S. Bon, Edson Luiz da Silva Lima, Octávio Augusto Ceva Antunes,

Microbial Metabolic Engineering and Bioproduction

Herein, different microorganisms were tested in the enantioselective reduction of ethyl 2-oxo-4-phenylbutyrate in aqueous medium for the preparation of ethyl (R)-2-hydroxy-4-phenylbutyrate, a key intermediate in the production of angiotensin converting enzyme (ACE) inhibitors. The use of Pichia angusta led to the (R)-enantiomer in 81% ee.