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Evaluation of four different equations for calculating LDL-C with eight different direct HDL-C assays

2013; Elsevier BV; Volume: 423; Linguagem: Inglês

10.1016/j.cca.2013.04.009

1873-3492

Marcelo Jose Andrade Oliveira, Hendrick E. van Deventer, Lorin M Bachmann, G. Russell Warnick, Katsuyuki Nakajima, M Nakamura, Ikunosuke Sakurabayashi, Mary M. Kimberly, Robert D. Shamburek, William J. Korzun, Gary L. Myers, W. Greg Miller, Alan T. Remaley,

Cardiovascular Function and Risk Factors

Low-density lipoprotein cholesterol (LDL-C) is often calculated (cLDL-C) by the Friedewald equation, which requires high-density lipoprotein cholesterol (HDL-C) and triglycerides (TG). Because there have been considerable changes in the measurement of HDL-C with the introduction of direct assays, several alternative equations have recently been proposed.We compared 4 equations (Friedewald, Vujovic, Chen, and Anandaraja) for cLDL-C, using 8 different direct HDL-C (dHDL-C) methods. LDL-C values were calculated by the 4 equations and determined by the β quantification reference method procedure in 164 subjects.For normotriglyceridemic samples (TG 200mg/dl) showed a large cardiovascular risk misclassification rate (30%-50%) for all combinations of dHDL-C assays and cLDL-C equations.The Friedewald equation showed the best performance for estimating LDL-C, but its accuracy varied considerably depending on the specific dHDL-C assay used. None of the cLDL-C equations performed adequately for hypertriglyceridemic samples.